1wlh: Difference between revisions
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= ABPC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 Dictyostelium discoideum]) | |GENE= ABPC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 Dictyostelium discoideum]) | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1ksr|1KSR]], [[1qfh|1QFH]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wlh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wlh OCA], [http://www.ebi.ac.uk/pdbsum/1wlh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wlh RCSB]</span> | |||
}} | }} | ||
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[[Category: rod domain]] | [[Category: rod domain]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:37:51 2008'' | ||
Revision as of 00:37, 31 March 2008
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| , resolution 2.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | ABPC (Dictyostelium discoideum) | ||||||
| Related: | 1KSR, 1QFH
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Molecular structure of the rod domain of Dictyostelium filamin
OverviewOverview
Dictyostelium discoideum filamin (ddFLN) is a two-chain F-actin crosslinking protein with an N-terminal actin-binding domain and a rod domain constructed from six tandem repeats of a 100 residue motif that has an immunoglobulin (Ig) fold. We report the 2.8 A resolution crystal structure of a homodimer of rod repeats 4, 5 and 6. The two chains are arranged in an antiparallel fashion and form an elongated element, which is shortened, however, compared to a fully extended, linear configuration because the long axis of each Ig domain is arranged at an angle to the long axis of the rod. Same arrangement of repeats should also be present in the rod domain of human FLNa, much longer than Dictyostelium FLN, which forms an extended structure able to crosslink F-actin chains over distances of more than 1000 A.
About this StructureAbout this Structure
1WLH is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.
ReferenceReference
Molecular structure of the rod domain of dictyostelium filamin., Popowicz GM, Muller R, Noegel AA, Schleicher M, Huber R, Holak TA, J Mol Biol. 2004 Oct 1;342(5):1637-46. PMID:15364587
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