P73: Difference between revisions

Revision as of 15:05, 24 August 2017

p73 is a protein related to p53 tumor suppressor. It is involved in cell cycle regulation and induction of apoptosis^[1]. p73 has several variants differing in their C- or N-terminal. p73 contains DNA-binding domain (DBD residues 112-312); tetramerization domain (TD residues 351-398).

Structural highlights

Human p73 DNA-binding domain complex with Tris, glycerol and Zn+2 ion (grey), 2xwc

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3D Structures of p733D Structures of p73

Updated on 24-August-2017

1cok – hp73 C terminal – human – NMR

2kby – hp73 TD – NMR

2wqi, 2wqj, 2wtt - hp73 TD

2xwc – hp73 DBD (mutant)
3vd0, 3vd1, 3vd2, 4g82, 4g83, 4guo, 4guq – hp73 DBD + DNA
4a63 – hp73 DBD + apoptosis stimulating of p53 protein

ReferencesReferences

↑ Di Como CJ, Gaiddon C, Prives C. p73 function is inhibited by tumor-derived p53 mutants in mammalian cells. Mol Cell Biol. 1999 Feb;19(2):1438-49. PMID:9891077

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Di Como CJ, Gaiddon C, Prives C. p73 function is inhibited by tumor-derived p53 mutants in mammalian cells. Mol Cell Biol. 1999 Feb;19(2):1438-49. PMID:9891077

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	<StructureSection load='' size='400' side='right' caption='Human p73 DNA-binding domain complex with Tris, glycerol and Zn+2 ion (grey), [[2xwc]]' scene='46/468230/Cv/1' pspeed='8'>		<StructureSection load='' size='400' side='right' caption='Human p73 DNA-binding domain complex with Tris, glycerol and Zn+2 ion (grey), [[2xwc]]' scene='46/468230/Cv/2' pspeed='8'>