1wcd: Difference between revisions
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wcd OCA], [http://www.ebi.ac.uk/pdbsum/1wcd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wcd RCSB]</span> | |||
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:34:22 2008'' | ||
Revision as of 00:34, 31 March 2008
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF IBDV T1 VIRUS-LIKE PARTICLE REVEALS A MISSING LINK IN ICOSAHEDRAL VIRUSES EVOLUTION
OverviewOverview
Double-stranded RNA virions are transcriptionally competent icosahedral particles that must translocate across a lipid bilayer to function within the cytoplasm of the target cell. Birnaviruses are unique among dsRNA viruses as they have a single T = 13 icosahedral shell, lacking the characteristic inner capsid observed in the others. We determined the crystal structures of the T = 1 subviral particle (260 angstroms in diameter) and of the T = 13 intact virus particle (700 angstroms in diameter) of an avian birnavirus to 3 angstroms and 7 angstroms resolution, respectively. Our results show that VP2, the only component of the virus icosahedral capsid, is homologous both to the capsid protein of positive-strand RNA viruses, like the T = 3 nodaviruses, and to the T = 13 capsid protein of members of the Reoviridae family of dsRNA viruses. Together, these results provide important insights into the multiple functions of the birnavirus capsid and reveal unexpected structural relationships among icosahedral viruses.
About this StructureAbout this Structure
1WCD is a Single protein structure of sequence from Infectious bursal disease virus. Full crystallographic information is available from OCA.
ReferenceReference
The birnavirus crystal structure reveals structural relationships among icosahedral viruses., Coulibaly F, Chevalier C, Gutsche I, Pous J, Navaza J, Bressanelli S, Delmas B, Rey FA, Cell. 2005 Mar 25;120(6):761-72. PMID:15797378
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OCA- Pages with broken file links
- Infectious bursal disease virus
- Single protein
- Bressanelli, S.
- Chevalier, C.
- Coulibaly, F.
- Delmas, B.
- Gutsche, I.
- Navaza, J.
- Pous, J.
- Rey, F A.
- Birnavirus
- Double-stranded rna virus protein
- Evolution
- Hydrolase
- Icosahedral virus
- Membrane translocation activity
- Non-enveloped icosahedral viruse
- Transcriptase machinery