4whw: Difference between revisions

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'''Unreleased structure'''


The entry 4whw is ON HOLD until Paper Publication
==Direct photocapture of bromodomains using tropolone chemical probes==
<StructureSection load='4whw' size='340' side='right' caption='[[4whw]], [[Resolution|resolution]] 1.34&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4whw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WHW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3OT:2-METHOXY-4-{1-[2-(MORPHOLIN-4-YL)ETHYL]-2-(2-PHENYLETHYL)-1H-BENZIMIDAZOL-5-YL}CYCLOHEPTA-2,4,6-TRIEN-1-ONE'>3OT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4whw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4whw OCA], [http://pdbe.org/4whw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4whw RCSB], [http://www.ebi.ac.uk/pdbsum/4whw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4whw ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>  
== Function ==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).


Authors: Hett, E.C., Piatnitski Chekler, E.L., Basak, A., Bonin, P.D., Denny, R.A., Flick, A.C., Geoghegan, K.F., Liu, S., Pletcher, M.T., Robinson, R.P., Sahasrabudhe, P., Salter, S., Stock, I.A., Jones, L.H.
==See Also==
 
*[[Bromodomain-containing protein|Bromodomain-containing protein]]
Description: Direct photocapture of bromodomains using tropolone chemical probes
== References ==
[[Category: Unreleased Structures]]
<references/>
__TOC__
</StructureSection>
[[Category: Basak, A]]
[[Category: Bonin, P D]]
[[Category: Chekler, E L.Piatnitski]]
[[Category: Denny, R A]]
[[Category: Flick, A C]]
[[Category: Geoghegan, K F]]
[[Category: Hett, E C]]
[[Category: Jones, L H]]
[[Category: Liu, S]]
[[Category: Pletcher, M T]]
[[Category: Robinson, R P]]
[[Category: Sahasrabudhe, P]]
[[Category: Sahasrabudhe, P]]
[[Category: Salter, S]]
[[Category: Salter, S]]
[[Category: Bonin, P.D]]
[[Category: Stock, I A]]
[[Category: Jones, L.H]]
[[Category: Brd4]]
[[Category: Denny, R.A]]
[[Category: Bromo domain]]
[[Category: Stock, I.A]]
[[Category: Inhibitor]]
[[Category: Robinson, R.P]]
[[Category: Transcription-transcription inhibitor complex]]
[[Category: Hett, E.C]]
[[Category: Flick, A.C]]
[[Category: Liu, S]]
[[Category: Geoghegan, K.F]]
[[Category: Pletcher, M.T]]
[[Category: Basak, A]]
[[Category: Piatnitski Chekler, E.L]]

Revision as of 19:52, 18 August 2017

Direct photocapture of bromodomains using tropolone chemical probesDirect photocapture of bromodomains using tropolone chemical probes

Structural highlights

4whw is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

See Also

References

  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

4whw, resolution 1.34Å

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