Leucine transporter: Difference between revisions
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<StructureSection load='3usg' size='350' side='right' caption='Structure of leucine transporter complex with leucine, lipid membrane fragments and Na+ | <StructureSection load='3usg' size='350' side='right' caption='Structure of leucine transporter complex with leucine, lipid membrane fragments and Na+ ions (purple) (PDB entry [[3usg]])' scene='56/564069/Cv/1'> | ||
== Function == | == Function == | ||
'''Leucine transporter''' (LeuT) is a membrane protein which is comprised of 12 transmembrane helices forming a channel. LeuT clears the synapse after signal transduction. LeuT utilizes the electrochemical potential gradient of Na+ ions across the membrane to catalyze the uptake of leucine. The LeuT is a homodimer<ref>PMID:15980244</ref>. | '''Leucine transporter''' (LeuT) is a membrane protein which is comprised of 12 transmembrane helices forming a channel. LeuT clears the synapse after signal transduction. LeuT utilizes the electrochemical potential gradient of Na+ ions across the membrane to catalyze the uptake of leucine. The LeuT is a homodimer<ref>PMID:15980244</ref>. | ||
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== Structural highlights == | == Structural highlights == | ||
The leucine binding pocket of LeuT contains 2 Na+ ions<ref>PMID:22245965</ref>. | <scene name='56/564069/Cv/2'>Leucine transporter complex with leucine, lipid membrane fragments and Na+ ions</scene>. The leucine binding pocket of LeuT contains 2 Na+ ions<ref>PMID:22245965</ref>. | ||
==3D structures of leucine transporter== | ==3D structures of leucine transporter== | ||