5via: Difference between revisions

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-'''Unreleased structure'''
-The entry 5via is ON HOLD  until Paper Publication
+==Crystal structural of Leishmania major pseudoperoxidase==
+<StructureSection load='5via' size='340' side='right' caption='[[5via]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5via]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VIA FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5via FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5via OCA], [http://pdbe.org/5via PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5via RCSB], [http://www.ebi.ac.uk/pdbsum/5via PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5via ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Leishmania major pseudoperoxidase (LmPP) is a recently discovered heme protein expressed by the human pathogen. Previous in vivo and in vitro studies suggest that LmPP is a crucial element of the pathogen's defense mechanism against the reactive nitrogen species peroxynitrite produced during the host immune response. To shed light on the potential mechanism of peroxynitrite detoxification, we have determined the 1.76-A X-ray crystal structure of LmPP, revealing a striking degree of homology with heme peroxidases. The most outstanding structural feature is a Cys/His heme coordination, which corroborates previous spectroscopic and mutagenesis studies. We also used a combination of stopped-flow and electron paramagnetic spectroscopies that together suggest that peroxynitrite is not a substrate for LmPP catalysis, leaving the function of LmPP an open question.
-Authors: Chreifi, G., Dejam, D., Poulos, T.L.
+Crystal structure and functional analysis of Leishmania major pseudoperoxidase.,Chreifi G, Dejam D, Poulos TL J Biol Inorg Chem. 2017 Aug;22(6):919-927. doi: 10.1007/s00775-017-1469-9. Epub, 2017 Jun 5. PMID:28584975<ref>PMID:28584975</ref>
-Description: Crystal structural of Leishmania major pseudoperoxidase
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 5via" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Chreifi, G]]
 [[Category: Dejam, D]]
-[[Category: Chreifi, G]]
+[[Category: Poulos, T L]]
-[[Category: Poulos, T.L]]
+[[Category: Heme protein]]
+[[Category: Oxidoreductase]]
+[[Category: Peroxidase]]