1vyx: Difference between revisions
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|PDB= 1vyx |SIZE=350|CAPTION= <scene name='initialview01'>1vyx</scene> | |PDB= 1vyx |SIZE=350|CAPTION= <scene name='initialview01'>1vyx</scene> | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyx OCA], [http://www.ebi.ac.uk/pdbsum/1vyx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1vyx RCSB]</span> | |||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
1VYX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ | 1VYX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYX OCA]. | ||
==Reference== | ==Reference== | ||
Solution structure of the Kaposi's sarcoma-associated herpesvirus K3 N-terminal domain reveals a Novel E2-binding C4HC3-type RING domain., Dodd RB, Allen MD, Brown SE, Sanderson CM, Duncan LM, Lehner PJ, Bycroft M, Read RJ, J Biol Chem. 2004 Dec 17;279(51):53840-7. Epub 2004 Sep 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15465811 15465811] | Solution structure of the Kaposi's sarcoma-associated herpesvirus K3 N-terminal domain reveals a Novel E2-binding C4HC3-type RING domain., Dodd RB, Allen MD, Brown SE, Sanderson CM, Duncan LM, Lehner PJ, Bycroft M, Read RJ, J Biol Chem. 2004 Dec 17;279(51):53840-7. Epub 2004 Sep 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15465811 15465811] | ||
[[Category: Human herpesvirus | [[Category: Human herpesvirus 8]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Allen, M D.]] | [[Category: Allen, M D.]] | ||
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[[Category: Read, R J.]] | [[Category: Read, R J.]] | ||
[[Category: Sanderson, C M.]] | [[Category: Sanderson, C M.]] | ||
[[Category: cross-brace motif]] | [[Category: cross-brace motif]] | ||
[[Category: ring domain]] | [[Category: ring domain]] | ||
[[Category: zinc-binding protein]] | [[Category: zinc-binding protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:28:52 2008'' | ||
Revision as of 00:28, 31 March 2008
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SOLUTION STRUCTURE OF THE KSHV K3 N-TERMINAL DOMAIN
OverviewOverview
RING domains are found in a large number of eukaryotic proteins. Most function as E3 ubiquitin-protein ligases, catalyzing the terminal step in the ubiquitination process. Structurally, these domains have been characterized as binding two zinc ions in a stable cross-brace motif. The tumorigenic human gamma-herpesvirus Kaposi's sarcoma-associated herpesvirus encodes a ubiquitin-protein ligase termed K3, which functions as an immune evasion molecule by ubiquitinating major histocompatibility complex class I. K3 possesses at its N terminus a domain related to cellular RING domains but with an altered zinc ligand arrangement. This domain was initially characterized as a plant homeodomain, a structure not previously known to function as an E3. Here, it is conclusively demonstrated that the K3 N-terminal domain is a variant member of the RING domain family and not a plant homeodomain. The domain is found to interact with the cellular ubiquitin-conjugating enzymes UbcH5A to -C and UbcH13, which dock to the equivalent surface as on classical cellular RING domains. Interaction with UbcH13 suggests a possible role for K3 in catalyzing Lys(63)-linked ubiquitination.
About this StructureAbout this Structure
1VYX is a Single protein structure of sequence from Human herpesvirus 8. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure of the Kaposi's sarcoma-associated herpesvirus K3 N-terminal domain reveals a Novel E2-binding C4HC3-type RING domain., Dodd RB, Allen MD, Brown SE, Sanderson CM, Duncan LM, Lehner PJ, Bycroft M, Read RJ, J Biol Chem. 2004 Dec 17;279(51):53840-7. Epub 2004 Sep 30. PMID:15465811
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