2wmx: Difference between revisions
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== | |||
==Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors== | |||
<StructureSection load='2wmx' size='340' side='right' caption='[[2wmx]], [[Resolution|resolution]] 2.45Å' scene=''> | <StructureSection load='2wmx' size='340' side='right' caption='[[2wmx]], [[Resolution|resolution]] 2.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wmx]] is a 1 chain structure | <table><tr><td colspan='2'>[[2wmx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WMX FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZY6:1-[(2S)-4-(5-PHENYL-1H-PYRAZOLO[3,4-B]PYRIDIN-4-YL)MORPHOLIN-2-YL]METHANAMINE'>ZY6</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZY6:1-[(2S)-4-(5-PHENYL-1H-PYRAZOLO[3,4-B]PYRIDIN-4-YL)MORPHOLIN-2-YL]METHANAMINE'>ZY6</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cgx|2cgx]], [[2c3j|2c3j]], [[2bro|2bro]], [[2brb|2brb]], [[2brh|2brh]], [[2cgv|2cgv]], [[2c3k|2c3k]], [[1nvr|1nvr]], [[1zlt|1zlt]], [[2cgw|2cgw]], [[2brn|2brn]], [[2ayp|2ayp]], [[1zys|1zys]], [[2cgu|2cgu]], [[1ia8|1ia8]], [[2br1|2br1]], [[2brg|2brg]], [[1nvs|1nvs]], [[2brm|2brm]], [[1nvq|1nvq]], [[2wms|2wms]], [[2c3l|2c3l]], [[2wmq|2wmq]], [[2wmr|2wmr]], [[2wmt|2wmt]], [[2wmu|2wmu]], [[2wmv|2wmv]], [[2wmw|2wmw]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cgx|2cgx]], [[2c3j|2c3j]], [[2bro|2bro]], [[2brb|2brb]], [[2brh|2brh]], [[2cgv|2cgv]], [[2c3k|2c3k]], [[1nvr|1nvr]], [[1zlt|1zlt]], [[2cgw|2cgw]], [[2brn|2brn]], [[2ayp|2ayp]], [[1zys|1zys]], [[2cgu|2cgu]], [[1ia8|1ia8]], [[2br1|2br1]], [[2brg|2brg]], [[1nvs|1nvs]], [[2brm|2brm]], [[1nvq|1nvq]], [[2wms|2wms]], [[2c3l|2c3l]], [[2wmq|2wmq]], [[2wmr|2wmr]], [[2wmt|2wmt]], [[2wmu|2wmu]], [[2wmv|2wmv]], [[2wmw|2wmw]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wmx OCA], [http://pdbe.org/2wmx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wmx RCSB], [http://www.ebi.ac.uk/pdbsum/2wmx PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wmx OCA], [http://pdbe.org/2wmx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wmx RCSB], [http://www.ebi.ac.uk/pdbsum/2wmx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wmx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Aherne, G W]] | [[Category: Aherne, G W]] | ||
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[[Category: Klair, S]] | [[Category: Klair, S]] | ||
[[Category: Matthews, T P]] | [[Category: Matthews, T P]] | ||
[[Category: | [[Category: McHardy, T]] | ||
[[Category: Montfort, R Van]] | [[Category: Montfort, R Van]] | ||
[[Category: Reader, J]] | [[Category: Reader, J]] | ||
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[[Category: Checkpoint kinase]] | [[Category: Checkpoint kinase]] | ||
[[Category: Chk1]] | [[Category: Chk1]] | ||
[[Category: Cytoplasm]] | |||
[[Category: Dna damage]] | [[Category: Dna damage]] | ||
[[Category: Dna repair]] | [[Category: Dna repair]] | ||
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[[Category: Nucleus]] | [[Category: Nucleus]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
[[Category: Polymorphism]] | |||
[[Category: Serine/threonine kinase]] | [[Category: Serine/threonine kinase]] | ||
[[Category: Serine/threonine-protein kinase]] | [[Category: Serine/threonine-protein kinase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Ubl conjugation]] |