User:Dotan Shaniv/Sandbox 1: Difference between revisions

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</table>

== Function ==

Beta-adrenergic receptors are [[G_protein-coupled_receptor|G Protein-Coupled Receptors]], i.e. ~~they mediate the~~ catecholamine-induced activation of [[adenylate cyclase]] through the action of [[GTP-binding_protein|G proteins]]. ~~The beta~~-2-adrenergic ~~receptor is~~ widely distributed in the respiratory tract and is found on many types of cells there, such as smooth muscle cells, epithelial and endothelial cells, mast cells and more<ref>PMID: 16387578</ref>. The natural ligands for adrenoceptors are epinephrine\norepinephrine (it may be worth noting that the beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine). When these ligands bind to adrenoceptors they activate them (they are their natural agonists), which in the case of the beta-2-adrenergic receptor translates to the sympathetic effect in the respiratory tract, namely, bronchodilation. This is the reason that beta-2-adrenergic receptors are the main target in [http://en.wikipedia.org/wiki/Asthma Asthma] treatment - drugs that function as beta-2 agonists help to activate these receptors in a similar way to epinephrine\norepinephrine and help patients to deal with acute or chronic asthma symptoms.

Beta-adrenergic receptors are [[G_protein-coupled_receptor|G Protein-Coupled Receptors]], i.e. their action of catecholamine-induced activation of [[adenylate cyclase]] is mediated through the action of [[GTP-binding_protein|G proteins]]. Beta-2-adrenergic receptors are widely distributed in the respiratory tract and are found on many types of cells there, such as smooth muscle cells, epithelial and endothelial cells, mast cells and more<ref>PMID: 16387578</ref>. The natural ligands for adrenoceptors are epinephrine\norepinephrine (it may be worth noting that the beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine). When these ligands bind to adrenoceptors they activate them (they are their natural agonists), which in the case of the beta-2-adrenergic receptor translates to the sympathetic effect in the respiratory tract, namely, bronchodilation. This is the reason that beta-2-adrenergic receptors are the main target in [http://en.wikipedia.org/wiki/Asthma Asthma] treatment - drugs that function as beta-2 agonists help to activate these receptors in a similar way to epinephrine\norepinephrine and help patients to deal with acute or chronic asthma symptoms.

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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 </table>
 == Function ==
-Beta-adrenergic receptors are [[G_protein-coupled_receptor|G Protein-Coupled Receptors]], i.e. they mediate the catecholamine-induced activation of [[adenylate cyclase]] through the action of [[GTP-binding_protein|G proteins]]. The beta-2-adrenergic receptor is widely distributed in the respiratory tract and is found on many types of cells there, such as smooth muscle cells, epithelial and endothelial cells, mast cells and more<ref>PMID: 16387578</ref>. The natural ligands for adrenoceptors are epinephrine\norepinephrine (it may be worth noting that the beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine). When these ligands bind to adrenoceptors they activate them (they are their natural agonists), which in the case of the beta-2-adrenergic receptor translates to the sympathetic effect in the respiratory tract, namely, bronchodilation. This is the reason that beta-2-adrenergic receptors are the main target in [http://en.wikipedia.org/wiki/Asthma Asthma] treatment - drugs that function as beta-2 agonists help to activate these receptors in a similar way to epinephrine\norepinephrine and help patients to deal with acute or chronic asthma symptoms.
+Beta-adrenergic receptors are [[G_protein-coupled_receptor|G Protein-Coupled Receptors]], i.e. their action of catecholamine-induced activation of [[adenylate cyclase]] is mediated through the action of [[GTP-binding_protein|G proteins]]. Beta-2-adrenergic receptors are widely distributed in the respiratory tract and are found on many types of cells there, such as smooth muscle cells, epithelial and endothelial cells, mast cells and more<ref>PMID: 16387578</ref>. The natural ligands for adrenoceptors are epinephrine\norepinephrine (it may be worth noting that the beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine). When these ligands bind to adrenoceptors they activate them (they are their natural agonists), which in the case of the beta-2-adrenergic receptor translates to the sympathetic effect in the respiratory tract, namely, bronchodilation. This is the reason that beta-2-adrenergic receptors are the main target in [http://en.wikipedia.org/wiki/Asthma Asthma] treatment - drugs that function as beta-2 agonists help to activate these receptors in a similar way to epinephrine\norepinephrine and help patients to deal with acute or chronic asthma symptoms.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]