Lipase: Difference between revisions

Michal Harel (talk | contribs)
No edit summary
Michal Harel (talk | contribs)
No edit summary
Line 72: Line 72:
**[[1hpl]] – hLip – horse <br />
**[[1hpl]] – hLip – horse <br />
**[[1hlg]] – hLip – human - gastric<br />
**[[1hlg]] – hLip – human - gastric<br />
**[[3jw8]], [[3hju]] – mono-glyceride hLip<br />
**[[1jmy]] – hBSSL  <br />
**[[1jmy]] – hBSSL  <br />
**[[1akn]] – cBSSL – cattle <br />
**[[1akn]] – cBSSL – cattle <br />
Line 81: Line 80:
**[[1gpl]] – Lip – Guinea pig<br />
**[[1gpl]] – Lip – Guinea pig<br />
**[[3zpx]] – Lip – ''Ustilago maydis''<br />
**[[3zpx]] – Lip – ''Ustilago maydis''<br />
**[[4l3w]] – Lip catalytic domain – bread mold<br />
**[[4zrd]], [[4zre]] – Lip1 (mutant) – dandruff fungus<br />


*Prokaryote lipase:  
*Prokaryote lipase:  
Line 86: Line 87:
**[[3guu]], [[1lbs]], [[1lbt]], [[1tca]], [[1tcb]], [[1tcc]] – CaLipA – ''Candida antarctica''<br />
**[[3guu]], [[1lbs]], [[1lbt]], [[1tca]], [[1tcb]], [[1tcc]] – CaLipA – ''Candida antarctica''<br />
**[[2veo]] – CaLipA – closed state<br />
**[[2veo]] – CaLipA – closed state<br />
**[[4k6g]] – CaLipB<br />
**[[4k6g]], [[4zv7]], [[3w9b]], [[5a6v]], [[5a71]] – CaLipB<br />
**[[3icv]], [[4k5q]], [[4k6h]], [[4k6k]] – CaLipB (mutant) <br />
**[[3icv]], [[4k5q]], [[4k6h]], [[4k6k]] – CaLipB (mutant) <br />
**[[1gz7]], [[1lpm]], [[1lps]]– CrLip 2 – ''Candida  rugosa'' - closed state<br />
**[[1gz7]], [[1lpm]], [[1lps]]– CrLip 2 – ''Candida  rugosa'' - closed state<br />
Line 97: Line 98:
**[[2fx5]] – Lip – ''Pseudomonas mendocina''<br />
**[[2fx5]] – Lip – ''Pseudomonas mendocina''<br />
**[[1yzf]] – Lip – ''Enterococcus faecalis''<br />
**[[1yzf]] – Lip – ''Enterococcus faecalis''<br />
**[[1dt3]], [[1dt5]], [[1dte]], [[1du4]], [[1ein]], [[1tib]], [[4dyh]], [[4ea6]], [[4flf]], [[4gbg]], [[4gwl]] - TlLip - ''Thermomyces lanuginose''<br />
**[[1dt3]], [[1dt5]], [[1dte]], [[1du4]], [[1ein]], [[1tib]], [[4dyh]], [[4ea6]], [[4flf]], [[4gbg]], [[4gwl]], [[4zgb]] - TlLip - ''Thermomyces lanuginose''<br />
**[[5ap9]] – TlLip (mutant)<br />
**[[1jfr]] – Lip – ''Streptomyces exfoliates''<br />
**[[1jfr]] – Lip – ''Streptomyces exfoliates''<br />
**[[5mal]] – Lip – ''Streptomyces rimosus''<br />
**[[1oil]] – BcLip - ''Burkholderia cepacia''<br />
**[[1oil]] – BcLip - ''Burkholderia cepacia''<br />
**[[2lip]] – BcLip – open state<br />
**[[2lip]] – BcLip – open state<br />
Line 112: Line 115:
**[[3lip]], [[3a6z]] - Lip - ''Pseudomonas cepacia'' – open state<br />
**[[3lip]], [[3a6z]] - Lip - ''Pseudomonas cepacia'' – open state<br />
**[[1qge]], [[1tah]] – Lip – ''Pseudomonas glumae''<br />
**[[1qge]], [[1tah]] – Lip – ''Pseudomonas glumae''<br />
**[[2w22]] – Lip – ''Geobacillus thermocatenulatus''<br />
**[[2w22]] – GtLip – ''Geobacillus thermocatenulatus''<br />
**[[1ji3]], [[1ku0]], [[4fmp]] – Lip – ''Bacillus stearothermophilus''<br />
**[[5ce5]] – GtLip (mutant)<br />
**[[1ji3]], [[1ku0]], [[4fmp]], [[4x6u]]– BstLip – ''Bacillus stearothermophilus''<br />
**[[4x71]], [[4x7b]], [[4x85]] – BstLip (mutant)<br />
**[[1ah7]] - Lip – ''Bacillus cereus''<br />
**[[1ah7]] - Lip – ''Bacillus cereus''<br />
**[[2qxt]], [[2qxu]], [[1isp]], [[1i6w]], [[4fdm]] - BsLip  – ''Bacillus subtilis''<br />
**[[2qxt]], [[2qxu]], [[1isp]], [[1i6w]], [[4fdm]], [[5ct5]], [[5ct6]]  - BsLip  – ''Bacillus subtilis''<br />
**[[3d2a]], [[3d2b]], [[3d2c]], [[1t2n]], [[1t4m]], [[3qmm]], [[3qzu]], [[4fkb]] - BsLip (mutant) <br />
**[[3d2a]], [[3d2b]], [[3d2c]], [[1t2n]], [[1t4m]], [[3qmm]], [[3qzu]], [[4fkb]], [[5ct8]] - BsLip (mutant) <br />
**[[2ory]] – Lip – ''Photobacterium lypoliticum''<br />
**[[2ory]] – Lip – ''Photobacterium lypoliticum''<br />
**[[2z5g]], [[2dsn]] – GzLip T1 – ''Geobacillus zalihae''<br />
**[[2z5g]], [[2dsn]] – GzLip T1 – ''Geobacillus zalihae''<br />
Line 125: Line 130:
**[[3uue]], [[3uuf]] – Lip – ''Malassezia globosa''<br />
**[[3uue]], [[3uuf]] – Lip – ''Malassezia globosa''<br />
**[[4hs9]] – Lip – ''Proteus mirabilis''<br />
**[[4hs9]] – Lip – ''Proteus mirabilis''<br />
**[[4opm]] – Lip – ''Acinetobacter baumannii''<br />
**[[5ah0]] – Lip – ''Pelosinus fermentans''<br />
**[[5ah1]] – Lip – ''Clostridium botulinum''<br />
**[[5ch8]] – Lip (mutant) – ''Penicillium cyclopium''<br />


*Lipase/colipase complexes.  The colipase is a co-enzyme whose binding to lipase optimizes the enzymatic activity
*Lipase/colipase complexes.  The colipase is a co-enzyme whose binding to lipase optimizes the enzymatic activity
Line 150: Line 159:
*Lipase + inhibitors
*Lipase + inhibitors


**[[3jwe]], [[3pe6]] - mono-glyceride hLip + SAR629 – covalent inhibitor<br />
**[[3l1h]] – EstE5(LIPE)+FeCl3  – noninvasive inhibitor<br />
**[[3l1h]] – EstE5(LIPE)+FeCl3  – noninvasive inhibitor<br />
**[[3l1i]], [[3l1j]] - EstE5(LIPE)+CuSO4 – noninvasive inhibitor<br />
**[[3l1i]], [[3l1j]] - EstE5(LIPE)+CuSO4 – noninvasive inhibitor<br />
Line 173: Line 181:
**[[4kjx]] - TlLip + nitrobenzaldehyde + lauric acid<br />
**[[4kjx]] - TlLip + nitrobenzaldehyde + lauric acid<br />
**[[4n8s]] - TlLip + nitrobenzaldehyde + ethylacetoacetate<br />
**[[4n8s]] - TlLip + nitrobenzaldehyde + ethylacetoacetate<br />
**[[4s0x]] – TlLip + lauric acid<br />


*Lipase conjugated with analogs to its reaction intermediates
*Lipase conjugated with analogs to its reaction intermediates
Line 191: Line 200:
**[[4ke7]], [[4ke8]], [[4ke9]] – BaMAGL + ligand<br />
**[[4ke7]], [[4ke8]], [[4ke9]] – BaMAGL + ligand<br />
**[[4ke6]], [[4kea]] – BaMAGL (mutant) + ligand<br />
**[[4ke6]], [[4kea]] – BaMAGL (mutant) + ligand<br />
**[[3jwe]], [[3pe6]] – hMAGL + inhibitor<br />
**[[3jwe]], [[3pe6]], [[4uuq]] – hMAGL + inhibitor<br />
**[[4zwn]] – yMAGL – yeast<br />
**[[4zxf]] – yMAGLip + substrate analog<br />


*Lipase with substrate bound at active site
*Lipase with substrate bound at active site

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

David Canner, Joel L. Sussman, Eran Hodis, Alexander Berchansky, Michal Harel, Stephanie Schell, Natalie Ziegler, Quinn R. Murray, Katelyn Clark, Leben Tadesse, Eric Martz