Transducin: Difference between revisions
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== Function == | == Function == | ||
'''Transducin''' (TDN) or '''Heterotrimeric G protein''' or '''Guanine nucleotide-binding protein G''' is a heterotrimeric G protein containing 3 chains: α, β and γ which are organized in two subunits: α and βγ<ref>PMID:2534964</ref>. TDN is involved in phototransduction. The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II. The latter causes activation of TDN. Upon TDN activation the GDP bound to its α subunit is exchanged for the GTP from the cytoplasm. Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of | '''Transducin''' (TDN) or '''Heterotrimeric G protein''' or '''Guanine nucleotide-binding protein G''' is a <scene name='59/590984/Cv/2'>heterotrimeric G protein containing 3 chains: α, β and γ</scene> which are organized in two subunits: α and βγ<ref>PMID:2534964</ref>. TDN is involved in phototransduction. The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II. The latter causes activation of TDN. Upon TDN activation the GDP bound to its α subunit is exchanged for the GTP from the cytoplasm. Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TDN preventing its re-association with the α subunit. | ||
== Disease == | == Disease == | ||