5xf1: Difference between revisions

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'''Unreleased structure'''


The entry 5xf1 is ON HOLD
==Structure of the Full-length glucagon class B G protein-coupled receptor==
 
<StructureSection load='5xf1' size='340' side='right' caption='[[5xf1]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
Authors: Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.Y., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5xf1]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XF1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XF1 FirstGlance]. <br>
Description: Structure of the Full-length glucagon class B G protein-coupled receptor
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=97V:4-{[(4-CYCLOHEXYLPHENYL){[3-(METHYLSULFONYL)PHENYL]CARBAMOYL}AMINO]METHYL}-N-(1H-TETRAZOL-5-YL)BENZAMIDE'>97V</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5xez|5xez]]</td></tr>
[[Category: Wang, M]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
[[Category: Wu, X]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xf1 OCA], [http://pdbe.org/5xf1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xf1 RCSB], [http://www.ebi.ac.uk/pdbsum/5xf1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xf1 ProSAT]</span></td></tr>
[[Category: Sierra, R]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/GLR_HUMAN GLR_HUMAN]] This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
__TOC__
</StructureSection>
[[Category: Lysozyme]]
[[Category: Cai, X]]
[[Category: Cherezov, V]]
[[Category: Dai, A]]
[[Category: Dharmarajan, V]]
[[Category: Dharmarajan, V]]
[[Category: Zhang, H]]
[[Category: Dong, Y]]
[[Category: Dai, A]]
[[Category: Geng, Z]]
[[Category: Wu, B]]
[[Category: Graaf, C de]]
[[Category: Grant, T]]
[[Category: Griffin, P]]
[[Category: Han, G Y]]
[[Category: Hanson, M]]
[[Category: Jiang, H]]
[[Category: Lau, J]]
[[Category: Lin, G]]
[[Category: Liu, W]]
[[Category: Liu, W]]
[[Category: Yang, D]]
[[Category: Ma, L]]
[[Category: Grant, T]]
[[Category: Han, G.Y]]
[[Category: Nelson, G]]
[[Category: Nelson, G]]
[[Category: Qiao, A]]
[[Category: Reedtz-Runge, S]]
[[Category: Sierra, R]]
[[Category: Song, G]]
[[Category: Stevens, R]]
[[Category: Wang, M]]
[[Category: Weierstall, U]]
[[Category: Weierstall, U]]
[[Category: Stevens, R]]
[[Category: Wu, B]]
[[Category: Lau, J]]
[[Category: Wu, X]]
[[Category: Song, G]]
[[Category: Wu, Y]]
[[Category: Reedtz-Runge, S]]
[[Category: Yang, D]]
[[Category: Yang, H]]
[[Category: Yang, H]]
[[Category: Jiang, H]]
[[Category: Wu, Y]]
[[Category: Griffin, P]]
[[Category: Geng, Z]]
[[Category: Lin, G]]
[[Category: Yang, L]]
[[Category: Yang, L]]
[[Category: Qiao, A]]
[[Category: Zhang, H]]
[[Category: Dong, Y]]
[[Category: Ma, L]]
[[Category: Cherezov, V]]
[[Category: De Graaf, C]]
[[Category: Cai, X]]
[[Category: Zhao, Q]]
[[Category: Zhao, Q]]
[[Category: Hanson, M]]
[[Category: 7tm domain]]
[[Category: Class b]]
[[Category: Human gcgr receptor]]
[[Category: Lcp]]
[[Category: Membrane]]
[[Category: Signaling protein]]
[[Category: Xfel]]

Revision as of 16:53, 24 May 2017

Structure of the Full-length glucagon class B G protein-coupled receptorStructure of the Full-length glucagon class B G protein-coupled receptor

Structural highlights

5xf1 is a 6 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Activity:Lysozyme, with EC number 3.2.1.17
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[GLR_HUMAN] This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

5xf1, resolution 3.19Å

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OCA
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