5xez: Difference between revisions
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The | ==Structure of the Full-length glucagon class B G protein-coupled receptor== | ||
<StructureSection load='5xez' size='340' side='right' caption='[[5xez]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5xez]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XEZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XEZ FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=97V:4-{[(4-CYCLOHEXYLPHENYL){[3-(METHYLSULFONYL)PHENYL]CARBAMOYL}AMINO]METHYL}-N-(1H-TETRAZOL-5-YL)BENZAMIDE'>97V</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5xf1|5xf1]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xez OCA], [http://pdbe.org/5xez PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xez RCSB], [http://www.ebi.ac.uk/pdbsum/5xez PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xez ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GLR_HUMAN GLR_HUMAN]] This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Lysozyme]] | |||
[[Category: Cai, X]] | |||
[[Category: Cherezov, V]] | |||
[[Category: Dai, A]] | |||
[[Category: Dharmarajan, V]] | |||
[[Category: Dong, Y]] | |||
[[Category: Geng, Z]] | |||
[[Category: Graaf, C de]] | |||
[[Category: Grant, T]] | |||
[[Category: Griffin, P]] | |||
[[Category: Han, G Y]] | |||
[[Category: Hanson, M]] | |||
[[Category: Jiang, H]] | |||
[[Category: Lau, J]] | |||
[[Category: Lin, G]] | |||
[[Category: Liu, W]] | |||
[[Category: Ma, L]] | |||
[[Category: Nelson, G]] | |||
[[Category: Qiao, A]] | |||
[[Category: Reedtz-Runge, S]] | |||
[[Category: Sierra, R]] | |||
[[Category: Song, G]] | |||
[[Category: Stevens, R]] | |||
[[Category: Wang, M]] | |||
[[Category: Weierstall, U]] | |||
[[Category: Wu, B]] | |||
[[Category: Wu, X]] | |||
[[Category: Wu, Y]] | |||
[[Category: Yang, D]] | |||
[[Category: Yang, H]] | |||
[[Category: Yang, L]] | |||
[[Category: Zhang, H]] | |||
[[Category: Zhao, Q]] | |||
[[Category: 7tm domain]] | |||
[[Category: Class b]] | |||
[[Category: Human gcgr receptor]] | |||
[[Category: Lcp]] | |||
[[Category: Membrane]] | |||
[[Category: Signaling protein]] | |||
[[Category: Xfel]] | |||