4uu9: Difference between revisions
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==Crystal structure of the human c5a in complex with MEDI7814 a neutralising antibody== | ==Crystal structure of the human c5a in complex with MEDI7814 a neutralising antibody== | ||
<StructureSection load='4uu9' size='340' side='right' caption='[[4uu9]], [[Resolution|resolution]] 2.12Å' scene=''> | <StructureSection load='4uu9' size='340' side='right' caption='[[4uu9]], [[Resolution|resolution]] 2.12Å' scene=''> | ||
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<table><tr><td colspan='2'>[[4uu9]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UU9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UU9 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4uu9]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UU9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UU9 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uu9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uu9 RCSB], [http://www.ebi.ac.uk/pdbsum/4uu9 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uu9 OCA], [http://pdbe.org/4uu9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uu9 RCSB], [http://www.ebi.ac.uk/pdbsum/4uu9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uu9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis). | [[http://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis). | ||
==See Also== | |||
*[[Complement C5|Complement C5]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||