5uyu: Difference between revisions

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-'''Unreleased structure'''
-The entry 5uyu is ON HOLD  until Paper Publication
+==Crystal structure of BACE1 in complex with 2-aminooxazoline-3-azaxanthene compound 12==
+<StructureSection load='5uyu' size='340' side='right' caption='[[5uyu]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-Authors: Whittington, D.A., Long, A.M., Sickmier, E.A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5uyu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UYU FirstGlance]. <br>
-Description: Crystal structure of BACE1 in complex with 2-aminooxazoline-3-azaxanthene compound 12
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8QV:(5S)-3-(3,6-DIHYDRO-2H-PYRAN-4-YL)-7-[5-(PROP-1-YN-1-YL)PYRIDIN-3-YL]-5H-SPIRO[1-BENZOPYRANO[2,3-C]PYRIDINE-5,4-[1,3]OXAZOL]-2-AMINE'>8QV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-[[Category: Long, A.M]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uyu OCA], [http://pdbe.org/5uyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uyu RCSB], [http://www.ebi.ac.uk/pdbsum/5uyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uyu ProSAT]</span></td></tr>
-[[Category: Whittington, D.A]]
+</table>
-[[Category: Sickmier, E.A]]
+== Function ==
+[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Memapsin 2]]
+[[Category: Long, A M]]
+[[Category: Sickmier, E A]]
+[[Category: Whittington, D A]]
+[[Category: Alzheimers disease]]
+[[Category: Amyloid precursor protein]]
+[[Category: App]]
+[[Category: Aspartic protease]]
+[[Category: Hydrolase]]