4owp: Difference between revisions

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==Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteosome lid.==
==Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteosome lid.==
<StructureSection load='4owp' size='340' side='right' caption='[[4owp]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='4owp' size='340' side='right' caption='[[4owp]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4o8x|4o8x]], [[4o8y|4o8y]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4o8x|4o8x]], [[4o8y|4o8y]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4owp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4owp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4owp RCSB], [http://www.ebi.ac.uk/pdbsum/4owp PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4owp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4owp OCA], [http://pdbe.org/4owp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4owp RCSB], [http://www.ebi.ac.uk/pdbsum/4owp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4owp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==

Revision as of 16:19, 10 May 2017

Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteosome lid.Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteosome lid.

Structural highlights

4owp is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[RPN8_YEAST] Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.[1] [RPN11_YEAST] Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.[2]

References

  1. ↑ Glickman MH, Rubin DM, Fried VA, Finley D. The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol Cell Biol. 1998 Jun;18(6):3149-62. PMID:9584156
  2. ↑ Chen L, Romero L, Chuang SM, Tournier V, Joshi KK, Lee JA, Kovvali G, Madura K. Sts1 plays a key role in targeting proteasomes to the nucleus. J Biol Chem. 2011 Jan 28;286(4):3104-18. doi: 10.1074/jbc.M110.135863. Epub 2010 , Nov 12. PMID:21075847 doi:10.1074/jbc.M110.135863

4owp, resolution 2.35Å

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OCA
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