4tqe: Difference between revisions
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==Structure of tau peptide in complex with Tau5 antibody Fab fragment== | ==Structure of tau peptide in complex with Tau5 antibody Fab fragment== | ||
<StructureSection load='4tqe' size='340' side='right' caption='[[4tqe]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='4tqe' size='340' side='right' caption='[[4tqe]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tpr|4tpr]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tpr|4tpr]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tqe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tqe RCSB], [http://www.ebi.ac.uk/pdbsum/4tqe PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tqe OCA], [http://pdbe.org/4tqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tqe RCSB], [http://www.ebi.ac.uk/pdbsum/4tqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tqe ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/TAU_HUMAN TAU_HUMAN]] Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.<ref>PMID:21985311</ref> | [[http://www.uniprot.org/uniprot/TAU_HUMAN TAU_HUMAN]] Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.<ref>PMID:21985311</ref> | ||
==See Also== | |||
*[[Microtubule-associated protein|Microtubule-associated protein]] | |||
*[[Tau protein|Tau protein]] | |||
== References == | == References == | ||
<references/> | <references/> | ||