5jk5: Difference between revisions

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'''Unreleased structure'''


The entry 5jk5 is ON HOLD  until Paper Publication
==Phenylalanine hydroxylase from dictyostelium - BH2 complex==
 
<StructureSection load='5jk5' size='340' side='right' caption='[[5jk5]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
Authors: Zhuang, N., Lee, K.H.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5jk5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JK5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JK5 FirstGlance]. <br>
Description: Phenylalanine hydroxylase from dictyostelium -BH2 complex
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HBI:7,8-DIHYDROBIOPTERIN'>HBI</scene>, <scene name='pdbligand=PIN:PIPERAZINE-N,N-BIS(2-ETHANESULFONIC+ACID)'>PIN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jk6|5jk6]], [[5jk8|5jk8]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jk5 OCA], [http://pdbe.org/5jk5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jk5 RCSB], [http://www.ebi.ac.uk/pdbsum/5jk5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jk5 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PH4H_DICDI PH4H_DICDI]] Hydroxylates L-tryptophan to 5-hydroxy-L-tryptophan but does not hydroxylate L-tyrosine to L-DOPA. It uses D-threo-tetrahydrodictyopterin (DH4), also known as dictyoperin, as a cofactor.<ref>PMID:18835579</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Lee, K H]]
[[Category: Zhuang, N]]
[[Category: Zhuang, N]]
[[Category: Lee, K.H]]
[[Category: Dictyostelium]]
[[Category: Enzyme regulation]]
[[Category: Oxidoreductase]]
[[Category: Phenylalanine hydroxylase]]
[[Category: Tetrahydrobiopterin]]

Revision as of 16:58, 27 April 2017

Phenylalanine hydroxylase from dictyostelium - BH2 complexPhenylalanine hydroxylase from dictyostelium - BH2 complex

Structural highlights

5jk5 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PH4H_DICDI] Hydroxylates L-tryptophan to 5-hydroxy-L-tryptophan but does not hydroxylate L-tyrosine to L-DOPA. It uses D-threo-tetrahydrodictyopterin (DH4), also known as dictyoperin, as a cofactor.[1]

References

  1. ↑ Siltberg-Liberles J, Steen IH, Svebak RM, Martinez A. The phylogeny of the aromatic amino acid hydroxylases revisited by characterizing phenylalanine hydroxylase from Dictyostelium discoideum. Gene. 2008 Dec 31;427(1-2):86-92. doi: 10.1016/j.gene.2008.09.005. Epub 2008 Sep , 16. PMID:18835579 doi:http://dx.doi.org/10.1016/j.gene.2008.09.005

5jk5, resolution 2.07Å

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OCA
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