5eg6: Difference between revisions

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'''Unreleased structure'''


The entry 5eg6 is ON HOLD  until Paper Publication
==CSL-RITA complex bound to DNA==
 
<StructureSection load='5eg6' size='340' side='right' caption='[[5eg6]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
Authors: Tabaja, N.H., Kovall, R.A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5eg6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EG6 FirstGlance]. <br>
Description: CSL-RITA complex bound to DNA
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eg6 OCA], [http://pdbe.org/5eg6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eg6 RCSB], [http://www.ebi.ac.uk/pdbsum/5eg6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eg6 ProSAT]</span></td></tr>
[[Category: Kovall, R.A]]
</table>
[[Category: Tabaja, N.H]]
== Function ==
[[http://www.uniprot.org/uniprot/SUH_MOUSE SUH_MOUSE]] Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.<ref>PMID:7566092</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Kovall, R A]]
[[Category: Tabaja, N H]]
[[Category: Notch]]
[[Category: Rbpj]]
[[Category: Transcription-dna binding protein-dna complex]]

Revision as of 16:56, 27 April 2017

CSL-RITA complex bound to DNACSL-RITA complex bound to DNA

Structural highlights

5eg6 is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SUH_MOUSE] Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.[1]

References

  1. ↑ Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, Israel A. Signalling downstream of activated mammalian Notch. Nature. 1995 Sep 28;377(6547):355-8. PMID:7566092 doi:http://dx.doi.org/10.1038/377355a0

5eg6, resolution 2.09Å

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