Pantothenate kinase: Difference between revisions
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<StructureSection load='2f9w' size='450' side='right' caption='Pantothenate kinase III dimer complex with pantothenate, glycerol and ethane diol, [[2f9w]]' scene='' pspeed='8'> | |||
== Function == | == Function == | ||
'''Pantothenate kinase''' (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis<ref>. PanK is regulated by feedback inhibition by CoA and its thioesters.PMID:9890959</ref>.<br /> | '''Pantothenate kinase''' (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis<ref>. PanK is regulated by feedback inhibition by CoA and its thioesters.PMID:9890959</ref>.<br /> | ||
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Pantothenate binds in a buried pocket at the PanK dimer interface<ref>PMID:16905099</ref>. | Pantothenate binds in a buried pocket at the PanK dimer interface<ref>PMID:16905099</ref>. | ||
</StructureSection> | |||
==3D structures of pantothenate kinase== | ==3D structures of pantothenate kinase== | ||