Sandbox Reserved 1063: Difference between revisions

Adhesin Competence Regulator (<scene name='69/694230/Adcr_space_fill/1'>AdcR</scene>) is a transcriptional regulator that controls the activation of over seventy genes within the bacteria [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae''Streptococcus pneumoniae''] and is a member of the multiple antibiotic resistance regulator (MarR) protein family <ref>DOI:10.1093/nar/gku1304 </ref>. Members of the [http://www.cell.com/current-biology/abstract/S0960-9822(13)00016-X MarR] protein family conserve a number of features including a general triangular shape, a two fold pseudosymmetric homodimer, and a winged helix-turn-helix pattern [https://en.wikipedia.org/wiki/Helix-turn-helix (wHTH)] which can be seen in Figure 1. AdcR exhibits these conserved features as well. Additionally this structure calls for multiple zinc binding sites that facilitate protein conformational change allowing for DNA binding and regulation through the wHTH domain.