User:Sachin Sundar/Sandbox 1: Difference between revisions

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== Structure ==

Lovastatin mimics the binding of HMG-CoA substrate, therefore it is confirmed that these two structures are similar. The molecular formula of Lovastatin is C24H36O5 and the molecular weight is 405 Da. <ref name="nine">Masterjohn, C. (2005, July). Cholesterol's Importance to the Cell Membrane. Retrieved March 28, 2017, from http://www.cholesterol-and-health.com/Cholesterol-Cell-Membrane.html</~~ref~~> Lovastatin is in a lactone ring conformation when in the inactivated form. Lactones are cyclic esters, or a ring consisting of two or more carbon atoms and one oxygen atom with a ketone group located on one of the carbons adjacent to the other oxygen <ref name= "sixteen">http://www.sigmaaldrich.com/chemistry/chemistry-products.html?TablePage=16270948

Lovastatin mimics the binding of HMG-CoA substrate, therefore it is confirmed that these two structures are similar. The molecular formula of Lovastatin is C24H36O5 and the molecular weight is 405 Da. <ref name="nine">Masterjohn, C. (2005, July). Cholesterol's Importance to the Cell Membrane. Retrieved March 28, 2017, from http://www.cholesterol-and-health.com/Cholesterol-Cell-Membrane.html<ref/> Lovastatin is in a lactone ring conformation when in the inactivated form. Lactones are cyclic esters, or a ring consisting of two or more carbon atoms and one oxygen atom with a ketone group located on one of the carbons adjacent to the other oxygen <ref name= "sixteen">http://www.sigmaaldrich.com/chemistry/chemistry-products.html?TablePage=16270948

Chemistry Products No delete http://www.sigmaaldrich.com/chemistry/chemistry-products.html?TablePage=16270948 (accessed Apr 20, 2017)<ref/>

[[Media:lov2d.jpg|(Image of Lovastatin 2D Structure)]]. Hydroxymethylglutaryl-CoA (HMG-CoA) is an intermediate in the mevalonate pathway with a molecular formula of C27H44N7O20P3S and a molecular weight of 911.659 g/mol <ref name= "nineteen"> https://pubchem.ncbi.nlm.nih.gov/compound/445127

hydroxymethylglutaryl-CoA https://pubchem.ncbi.nlm.nih.gov/compound/445127 (accessed Apr 20, 2017).<ref/>

hydroxymethylglutaryl-CoA https://pubchem.ncbi.nlm.nih.gov/compound/445127 (accessed Apr 20, 2017)<ref/>

[[Media:hmgcoa2d.jpg|(Image of HMG-CoA 2D Structure)]]. The structure of HMG-CoA reductase in humans consists of a tetramer, which is the catalytic portion of this enzyme. The tetramer consists of monomers wrapped around each other in the form of two dimers. Within each dimer are two active sites formed by the residues in both monomers. Each monomer consists of three binding sites; two of which are the S and L domains and are connected via a cis-loop, and is essential for NADP binding <ref name= "eighteen">http://proteopedia.org/wiki/index.php/HMG-CoA_Reductase#cite_note-Meigs-2

[[Media:hmgcoa2d.jpg|(Image of HMG-CoA 2D Structure)]]. The structure of HMG-CoA reductase in humans consists of a tetramer, which is the catalytic portion of this enzyme. The tetramer consists of monomers wrapped around each other in the form of two dimers. Within each dimer are two active sites formed by the residues in both monomers. Each monomer consists of three binding sites; two of which are the S and L domains and are connected via a cis-loop, and is essential for NADP binding <ref name="eighteen">http://proteopedia.org/wiki/index.php/HMG-CoA_Reductase#cite_note-Meigs-2

HMG-CoA Reductase http://proteopedia.org/wiki/index.php/HMG-CoA_Reductase#cite_note-Meigs-2 (accessed Apr 20, 2017).<ref/>

HMG-CoA Reductase http://proteopedia.org/wiki/index.php/HMG-CoA_Reductase#cite_note-Meigs-2 (accessed Apr 20, 2017)<ref/>

[[Media:lovhmg.jpg|Image of 2D comparison of Lovastatin and HMG-CoA]]

==Mechanism==

@@ Line 19: / Line 19: @@
 == Structure ==
-Lovastatin mimics the binding of HMG-CoA substrate, therefore it is confirmed that these two structures are similar. The molecular formula of Lovastatin is C24H36O5 and the molecular weight is 405 Da. <ref name="nine">Masterjohn, C. (2005, July). Cholesterol's Importance to the Cell Membrane. Retrieved March 28, 2017, from http://www.cholesterol-and-health.com/Cholesterol-Cell-Membrane.html</ref> Lovastatin is in a lactone ring conformation when in the inactivated form. Lactones are cyclic esters, or a ring consisting of two or more carbon atoms and one oxygen atom with a ketone group located on one of the carbons adjacent to the other oxygen <ref name= "sixteen">http://www.sigmaaldrich.com/chemistry/chemistry-products.html?TablePage=16270948
+Lovastatin mimics the binding of HMG-CoA substrate, therefore it is confirmed that these two structures are similar. The molecular formula of Lovastatin is C24H36O5 and the molecular weight is 405 Da. <ref name="nine">Masterjohn, C. (2005, July). Cholesterol's Importance to the Cell Membrane. Retrieved March 28, 2017, from http://www.cholesterol-and-health.com/Cholesterol-Cell-Membrane.html<ref/> Lovastatin is in a lactone ring conformation when in the inactivated form. Lactones are cyclic esters, or a ring consisting of two or more carbon atoms and one oxygen atom with a ketone group located on one of the carbons adjacent to the other oxygen <ref name= "sixteen">http://www.sigmaaldrich.com/chemistry/chemistry-products.html?TablePage=16270948
 Chemistry Products No delete http://www.sigmaaldrich.com/chemistry/chemistry-products.html?TablePage=16270948 (accessed Apr 20, 2017)<ref/>
   [[Media:lov2d.jpg|(Image of Lovastatin 2D Structure)]].  Hydroxymethylglutaryl-CoA (HMG-CoA) is an intermediate in the mevalonate pathway with a molecular formula of C27H44N7O20P3S and a molecular weight of 911.659 g/mol <ref name= "nineteen"> https://pubchem.ncbi.nlm.nih.gov/compound/445127
-hydroxymethylglutaryl-CoA https://pubchem.ncbi.nlm.nih.gov/compound/445127 (accessed Apr 20, 2017).<ref/>
+hydroxymethylglutaryl-CoA https://pubchem.ncbi.nlm.nih.gov/compound/445127 (accessed Apr 20, 2017)<ref/>
-[[Media:hmgcoa2d.jpg|(Image of HMG-CoA 2D Structure)]]. The structure of HMG-CoA reductase in humans consists of a tetramer, which is the catalytic portion of this enzyme. The tetramer consists of monomers wrapped around each other in the form of two dimers. Within each dimer are two active sites formed by the residues in both monomers. Each monomer consists of three binding sites; two of which are the S and L domains and are connected via a cis-loop, and is essential for NADP binding <ref name= "eighteen">http://proteopedia.org/wiki/index.php/HMG-CoA_Reductase#cite_note-Meigs-2
+[[Media:hmgcoa2d.jpg|(Image of HMG-CoA 2D Structure)]]. The structure of HMG-CoA reductase in humans consists of a tetramer, which is the catalytic portion of this enzyme. The tetramer consists of monomers wrapped around each other in the form of two dimers. Within each dimer are two active sites formed by the residues in both monomers. Each monomer consists of three binding sites; two of which are the S and L domains and are connected via a cis-loop, and is essential for NADP binding <ref name="eighteen">http://proteopedia.org/wiki/index.php/HMG-CoA_Reductase#cite_note-Meigs-2
-HMG-CoA Reductase http://proteopedia.org/wiki/index.php/HMG-CoA_Reductase#cite_note-Meigs-2 (accessed Apr 20, 2017).<ref/>
+HMG-CoA Reductase http://proteopedia.org/wiki/index.php/HMG-CoA_Reductase#cite_note-Meigs-2 (accessed Apr 20, 2017)<ref/>
 [[Media:lovhmg.jpg|Image of 2D comparison of Lovastatin and HMG-CoA]]
 ==Mechanism==