Sandbox Reserved 1063: Difference between revisions
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== '''DNA Binding''' == | == '''DNA Binding''' == | ||
=== Helix-Turn-Helix Motif === | === Helix-Turn-Helix Motif === | ||
[[Image:Screen Shot 2017-04-18 at 11.56.32 PM.png|300 px|left|thumb|'''Figure 1'''. A generic protein representing the wHTH motif binding the major and minor groove of DNA similar to AdcR.]] | |||
The AdcR MarR transcriptional regulator's structure resembles the other proteins in the same family as mentioned before; however, the most notable differences are found in the winged helix-turn-helix (wHTH) motif that assists in binding DNA. This motif is characteristic of the MarR family and found within the DNA binding domain of the protein. The major groove of DNA is bound to the recognition helix while the wings of the motif grip onto the minor grooves of DNA <ref name="guerra" />. Although AdcR is a highly alpha helical protein, the "wings" of the wHTH motif consist of two anti parallel beta strands that are made up of positively charged residues. | The AdcR MarR transcriptional regulator's structure resembles the other proteins in the same family as mentioned before; however, the most notable differences are found in the winged helix-turn-helix (wHTH) motif that assists in binding DNA. This motif is characteristic of the MarR family and found within the DNA binding domain of the protein. The major groove of DNA is bound to the recognition helix while the wings of the motif grip onto the minor grooves of DNA <ref name="guerra" />. Although AdcR is a highly alpha helical protein, the "wings" of the wHTH motif consist of two anti parallel beta strands that are made up of positively charged residues. | ||