5v0l: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 5v0l is ON HOLD
==Crystal structure of the AHR-ARNT heterodimer in complex with the DRE==
 
<StructureSection load='5v0l' size='340' side='right' caption='[[5v0l]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
Authors: Seok, S.-H., Lee, W., Jiang, L., Bradfield, C.A., Xing, Y.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5v0l]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V0L FirstGlance]. <br>
Description: Crystal structure of the AHR-ARNT heterodimer in complex with the DRE
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v0l OCA], [http://pdbe.org/5v0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v0l RCSB], [http://www.ebi.ac.uk/pdbsum/5v0l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v0l ProSAT]</span></td></tr>
[[Category: Bradfield, C.A]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ARNT_HUMAN ARNT_HUMAN]] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia. [[http://www.uniprot.org/uniprot/AHR_MOUSE AHR_MOUSE]] Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.<ref>PMID:1314586</ref> <ref>PMID:7961644</ref> <ref>PMID:7969080</ref> <ref>PMID:8806883</ref> <ref>PMID:9427285</ref> <ref>PMID:10973493</ref> <ref>PMID:10639156</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bradfield, C A]]
[[Category: Jiang, L]]
[[Category: Lee, W]]
[[Category: Lee, W]]
[[Category: Seok, S H]]
[[Category: Xing, Y]]
[[Category: Xing, Y]]
[[Category: Jiang, L]]
[[Category: Ahr]]
[[Category: Seok, S.-H]]
[[Category: Arnt]]
[[Category: Heterodimer]]
[[Category: Transcription factor]]
[[Category: Transcription-dna complex]]

Revision as of 16:04, 19 April 2017

Crystal structure of the AHR-ARNT heterodimer in complex with the DRECrystal structure of the AHR-ARNT heterodimer in complex with the DRE

Structural highlights

5v0l is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ARNT_HUMAN] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia. [AHR_MOUSE] Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.[1] [2] [3] [4] [5] [6] [7]

References

  1. ↑ Ema M, Sogawa K, Watanabe N, Chujoh Y, Matsushita N, Gotoh O, Funae Y, Fujii-Kuriyama Y. cDNA cloning and structure of mouse putative Ah receptor. Biochem Biophys Res Commun. 1992 Apr 15;184(1):246-53. PMID:1314586
  2. ↑ Ema M, Ohe N, Suzuki M, Mimura J, Sogawa K, Ikawa S, Fujii-Kuriyama Y. Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors. J Biol Chem. 1994 Nov 4;269(44):27337-43. PMID:7961644
  3. ↑ Poland A, Palen D, Glover E. Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol Pharmacol. 1994 Nov;46(5):915-21. PMID:7969080
  4. ↑ Fernandez-Salguero PM, Hilbert DM, Rudikoff S, Ward JM, Gonzalez FJ. Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. Toxicol Appl Pharmacol. 1996 Sep;140(1):173-9. PMID:8806883 doi:http://dx.doi.org/S0041-008X(96)90210-0
  5. ↑ Mimura J, Yamashita K, Nakamura K, Morita M, Takagi TN, Nakao K, Ema M, Sogawa K, Yasuda M, Katsuki M, Fujii-Kuriyama Y. Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells. 1997 Oct;2(10):645-54. PMID:9427285
  6. ↑ Lahvis GP, Lindell SL, Thomas RS, McCuskey RS, Murphy C, Glover E, Bentz M, Southard J, Bradfield CA. Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10442-7. PMID:10973493 doi:http://dx.doi.org/10.1073/pnas.190256997
  7. ↑ Shimizu Y, Nakatsuru Y, Ichinose M, Takahashi Y, Kume H, Mimura J, Fujii-Kuriyama Y, Ishikawa T. Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):779-82. PMID:10639156

5v0l, resolution 4.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=5v0l&oldid=2742191"