Sandbox Reserved 1053: Difference between revisions

CzrA functions as a [https://en.wikipedia.org/wiki/Dimer_(chemistry) dimer]. The <scene name='69/694218/Monomeric_unit/1'>monomeric units</scene> dimerize at the czr operon, repressing gene transcription. Each monomeric unit contains <scene name='69/694218/Helices/1'>five alpha helices</scene> seen in purple and <scene name='69/694218/B_sheets/1'>two beta sheets</scene> displayed in yellow. While the function of the [https://en.wikipedia.org/wiki/Beta_sheet beta sheets] are not yet known, key [https://en.wikipedia.org/wiki/Alpha_helix helices] regulate the binding of DNA and Zn⁺². The <scene name='69/694220/2kjb_colored_alpha_4/1'>alpha 4 helices</scene> are the location of DNA binding and the <scene name='69/694220/2kjb_colored_alpha_5/1'>alpha 5 helices</scene> contain the Zn⁺² binding site. As Zn⁺² binds, the alpha 4 helices are <scene name='69/694220/2kjc_colored_alpha_4/1'>pushed out of alignment</scene>, repressing their DNA binding ability (Figure 2).