Sandbox Reserved 1072: Difference between revisions
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== Biological Function == | == Biological Function == | ||
[[Image:C-di-GMP.jpg |200 px|thumb|left|cyclic-dimeric-GMP]] | [[Image:C-di-GMP larger font.jpg |200 px|thumb|left|cyclic-dimeric-GMP]] | ||
[[Image:Poly B-1, 6 GlcNAc.jpg |150 px|left|thumb|poly-β-1,6-N-acetylglucosamine]] | [[Image:Poly B-1, 6 GlcNAc.jpg |150 px|left|thumb|poly-β-1,6-N-acetylglucosamine]] | ||
Diguanylate cyclases are a group of class 2 transferase enzymes that catalyze the production of cyclic dimeric-guanosine monophosphate (c-di-GMP), an important <span class="plainlinks">[https://en.wikipedia.org/wiki/Second_messenger_system second messenger]</span> for <span class="plainlinks">[https://en.wikipedia.org/wiki/Signal_transduction signal transduction]</span>. Signal transduction is the process of sending signals through cells to promote responses, most commonly through phosphorylation or dephosphorylation events. <span class="plainlinks">[https://en.wikipedia.org/wiki/Escherichia_coli ''Escherechia coli'']</span>, a gram-negative bacterium often found in the intestines of mammals, uses DgcZ in the synthesis of its <span class="plainlinks">[https://en.wikipedia.org/wiki/biofilm biofilm]</span>. Enzyme DgcZ from ''E. coli'' acts a catalyst to synthesize cyclic di-GMP from two substrate guanosine triphosphate (GTP) molecules to aid in communication of signals throughout the bacteria. C-di-GMP is a second messenger in the production of poly-β-1,6-N-acetylglucosamine (poly-GlcNAc), a polysaccharide required for ''E. coli'' biofilm production. This biofilm allows ''E. coli'' to adhere to extracellular surfaces. | Diguanylate cyclases are a group of class 2 transferase enzymes that catalyze the production of cyclic dimeric-guanosine monophosphate (c-di-GMP), an important <span class="plainlinks">[https://en.wikipedia.org/wiki/Second_messenger_system second messenger]</span> for <span class="plainlinks">[https://en.wikipedia.org/wiki/Signal_transduction signal transduction]</span>. Signal transduction is the process of sending signals through cells to promote responses, most commonly through phosphorylation or dephosphorylation events. <span class="plainlinks">[https://en.wikipedia.org/wiki/Escherichia_coli ''Escherechia coli'']</span>, a gram-negative bacterium often found in the intestines of mammals, uses DgcZ in the synthesis of its <span class="plainlinks">[https://en.wikipedia.org/wiki/biofilm biofilm]</span>. Enzyme DgcZ from ''E. coli'' acts a catalyst to synthesize cyclic di-GMP from two substrate guanosine triphosphate (GTP) molecules to aid in communication of signals throughout the bacteria. C-di-GMP is a second messenger in the production of poly-β-1,6-N-acetylglucosamine (poly-GlcNAc), a polysaccharide required for ''E. coli'' biofilm production. This biofilm allows ''E. coli'' to adhere to extracellular surfaces. | ||