Sandbox Reserved 1069: Difference between revisions

The <scene name='75/756372/Saltbridgelabel/1'>salt bridge</scene> formation between Lys77 and Asp207 of each domain of YiiP forms an interlocking <scene name='75/756372/Saltbridgeclear/1'>interaction</scene> that acts as the pivot point of the conformational change that drives the function of YiiP. Interlocking interactions are disrupted when Zn²⁺ is bound, due to movement of the antiparallel helices, causing a conformational shift in YiiP. This salt bridge also aids in holding the two monomers together, where [[Image:Saltbridge.png|200px|left|thumb|Lys77 and Asp207 Salt Bridges]]<scene name='75/756372/Hydrophobic1/1'>hydrophobic</scene> residues around the salt bridge further stabilize the two domains in the v-shaped void where the domains connect. This prevents degradation of the protein's interlock via interactions with the environment.