Sandbox Reserved 1063: Difference between revisions
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<StructureSection load='3TGN' size='350' side='right' caption='3TGN' scene='' /> | <StructureSection load='3TGN' size='350' side='right' caption='3TGN' scene='' /> | ||
== '''Zinc-Dependent Transcriptional Regulator AdcR''' == | =='''Zinc-Dependent Transcriptional Regulator AdcR'''== | ||
===Introduction=== | ===Introduction=== | ||
AdcR is a zinc-dependent transcriptional regulator that controls the activation of over seventy genes within the bacteria [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae''Streptococcus pneumoniae'']<ref>DOI:10.1093/nar/gku1304 </ref>. Zinc plays a vital role in organism homeostasis acting as a [https://en.wikipedia.org/wiki/Cofactor_(biochemistry) co-factor] and a regulator of enzymatic activity, however zinc can lead to cell toxicity and deficiency of other vital metals that are also necessary for protein function<ref> Fraústo da Silva J, Williams R. The Biological Chemistry of Elements: The Inorganic Chemistry of Life. Second ed. Oxford University Press; Oxford: 2001.</ref><ref> DOI: 10.1021/cr900077w</ref>. Given the importance of zinc in general homeostasis the vital role of AdcR in ''Streptococcus pneumoniae'' can be understood given its ability to regulate zinc transfer proteins within the bacteria. | AdcR is a zinc-dependent transcriptional regulator that controls the activation of over seventy genes within the bacteria [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae''Streptococcus pneumoniae'']<ref>DOI:10.1093/nar/gku1304 </ref>. Zinc plays a vital role in organism homeostasis acting as a [https://en.wikipedia.org/wiki/Cofactor_(biochemistry) co-factor] and a regulator of enzymatic activity, however zinc can lead to cell toxicity and deficiency of other vital metals that are also necessary for protein function<ref> Fraústo da Silva J, Williams R. The Biological Chemistry of Elements: The Inorganic Chemistry of Life. Second ed. Oxford University Press; Oxford: 2001.</ref><ref> DOI: 10.1021/cr900077w</ref>. Given the importance of zinc in general homeostasis the vital role of AdcR in ''Streptococcus pneumoniae'' can be understood given its ability to regulate zinc transfer proteins within the bacteria. | ||