Sandbox1996: Difference between revisions
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Chlorothiazide is a semisynthetic chemical compound known chemically as 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide (Figure 1) (reference). Its chemical formula is C7H8ClN3O4S2 and its molecular weight is of 298Da. This chemical compound consists of an aromatic ring, benzothiadiazine, a sulfonamide group, and a chloride. It has a melting point of 272 degrees Celsius, a flash point of 302.7 degrees Celcius, a solubility of 60 mg/m in DMSO and less than 1 mg/ml in water, and appears a white crystalline powder(reference). The structure was determined by X-Ray diffraction and was measured at a resolution of 2.1 Angstroms (reference). <scene name='75/756546/Drug/1'>Cholorothiazide was determined when bound to glutamate receptor 2 </scene>through hydrogen bonding between the nitrogen 12 and serine 242B, nitrogen 1 and serines 108B and 108E, and oxygen 17 and glycine 219 E (Figure 2 & 3). Synthesis of chlorothiazide occurs through the reaction between 3 -chloroaniline, chlorosulfonic acid, and ammonia; and it is catalyzed by formic acid (Figure 4)(reference). | Chlorothiazide is a semisynthetic chemical compound known chemically as 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide (Figure 1) (reference). Its chemical formula is C7H8ClN3O4S2 and its molecular weight is of 298Da. This chemical compound consists of an aromatic ring, benzothiadiazine, a sulfonamide group, and a chloride. It has a melting point of 272 degrees Celsius, a flash point of 302.7 degrees Celcius, a solubility of 60 mg/m in DMSO and less than 1 mg/ml in water, and appears a white crystalline powder(reference). The structure was determined by X-Ray diffraction and was measured at a resolution of 2.1 Angstroms (reference). <scene name='75/756546/Drug/1'>Cholorothiazide was determined when bound to glutamate receptor 2 </scene>through hydrogen bonding between the nitrogen 12 and serine 242B, nitrogen 1 and serines 108B and 108E, and oxygen 17 and glycine 219 E (Figure 2 & 3). Synthesis of chlorothiazide occurs through the reaction between 3 -chloroaniline, chlorosulfonic acid, and ammonia; and it is catalyzed by formic acid (Figure 4)(reference). | ||
<center>[[Image:Duiril.png|thumb|left|200px|Figure 1. | <center>[[Image:Duiril.png|thumb|left|200px|Figure 1. Molecular structure of chlorothiazide.]]</center> | ||
<center>[[Image:Diuril2.png|thumb|left|200px|Figure 2. Stabilizing structure between glutamate receptor 2 and chlorothiazide.]]</center> | <center>[[Image:Diuril2.png|thumb|left|200px|Figure 2. Stabilizing structure between glutamate receptor 2 and chlorothiazide.]]</center> | ||
<center>[[Image:Diuril3.png|thumb|left|200px|Figure 3. Stabilizing structure between glutamate receptor 2 and chlorothiazide.]]</center> | <center>[[Image:Diuril3.png|thumb|left|200px|Figure 3. Stabilizing structure between glutamate receptor 2 and chlorothiazide.]]</center> | ||