5pq7: Difference between revisions

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'''Unreleased structure'''


The entry 5pq7 is ON HOLD
==PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 44)==
 
<StructureSection load='5pq7' size='340' side='right' caption='[[5pq7]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
Authors: Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5pq7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5PQ7 FirstGlance]. <br>
Description: PanDDA analysis group deposition --Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 44)
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5pq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pq7 OCA], [http://pdbe.org/5pq7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5pq7 RCSB], [http://www.ebi.ac.uk/pdbsum/5pq7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5pq7 ProSAT]</span></td></tr>
[[Category: Pearce, N.M]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bradley, A R]]
[[Category: Brandao-Neto, J]]
[[Category: Brennan, P E]]
[[Category: Collins, P]]
[[Category: Collins, P]]
[[Category: Cox, O]]
[[Category: Cox, O]]
[[Category: Arrowsmith, C.H]]
[[Category: Delft, F von]]
[[Category: Brandao-Neto, J]]
[[Category: Dias, A]]
[[Category: Douangamath, A]]
[[Category: Edwards, A]]
[[Category: Fairhead, M]]
[[Category: Fairhead, M]]
[[Category: Von Delft, F]]
[[Category: Krojer, T]]
[[Category: MacLean, E]]
[[Category: Ng, J]]
[[Category: Pearce, N M]]
[[Category: Renjie, Z]]
[[Category: Renjie, Z]]
[[Category: Sethi, R]]
[[Category: Talon, R]]
[[Category: Wright, N]]
[[Category: Wright, N]]
[[Category: Ng, J]]
[[Category: Bromodomain]]
[[Category: Bradley, A.R]]
[[Category: Epigenetic]]
[[Category: Talon, R]]
[[Category: Gene regulation]]
[[Category: Brennan, P.E]]
[[Category: Pandda]]
[[Category: Edwards, A]]
[[Category: Sgc - diamond i04-1 fragment screening]]
[[Category: Douangamath, A]]
[[Category: Xchemexplorer]]
[[Category: Maclean, E]]
[[Category: Krojer, T]]
[[Category: Dias, A]]
[[Category: Sethi, R]]
[[Category: Bountra, C]]

Revision as of 16:51, 29 March 2017

PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 44)PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 44)

Structural highlights

5pq7 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BRD1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.[1] [2]

References

  1. ↑ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 2006 Jan 6;21(1):51-64. PMID:16387653 doi:10.1016/j.molcel.2005.12.007
  2. ↑ Qin S, Jin L, Zhang J, Liu L, Ji P, Wu M, Wu J, Shi Y. Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF). J Biol Chem. 2011 Oct 21;286(42):36944-55. doi: 10.1074/jbc.M111.244400. Epub, 2011 Aug 31. PMID:21880731 doi:http://dx.doi.org/10.1074/jbc.M111.244400

5pq7, resolution 1.56Å

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OCA
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