Sandbox Reserved 1066: Difference between revisions

No edit summary
No edit summary
Line 1: Line 1:
==Zn Transporter YiiP==
==Zn Transporter YiiP==
 
<StructureSection load='3h90' size='340' side='right' caption='Zn Transporter' scene=''>
This is a default text for your page '''Kyle Colston/Sandbox 1''<scene name='69/694233/Tm1/1'>TM1</scene>'. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
This is a default text for your page '''Kyle Colston/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.


Line 7: Line 7:
This protein is found in ''E. coli''
This protein is found in ''E. coli''


==Mechanism for Transport==
==Structure==
 
===Zn Induced Conformation Change===


==Zinc Induced Conformation Change==
===Allosteric Inhibition===


The ligand binding domains (CTD) and pore domains (TMD) are connected by the flexible loop that houses the charge interlock mechanism that helps hold the homodimer together. This flexible loop also acts as a hinge for the CTDs to come together and bind Zn at active site C. Zn binding to the CTD causes a conformation change in the TMD which ca
Zn binding to Active Site C causes a conformation change that reduces the affinity for Zn at Active Site A.


==Allosteric Inhibition==
== Function ==


Zn binding to Active Site C causes a conformation change that reduces the affinity for Zn at Active Site A.
== Disease ==


== Relevance ==


== Structural highlights ==


This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA, Stephanie Shoults, Joseph Thomas, Robin C. Gagnon, Geoffrey C. Hoops, Kyle Colston