Sandbox Reserved 1072: Difference between revisions
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{{Sandbox_Reserved_Butler_CH462_Sp2015_#}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_Reserved_Butler_CH462_Sp2015_#}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
==Diguanylate Cyclase DgcZ from Escherichia coli== | ==Diguanylate Cyclase DgcZ from Escherichia coli== | ||
<StructureSection load=' | <StructureSection load='4H54' size='340' side='right' caption='Diguanylate Cyclase DgcZ' scene=''> | ||
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
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====3His/1Cys Motif==== | ====3His/1Cys Motif==== | ||
== Mechanism of Action == | == Mechanism of Action == | ||
<scene name='69/694239/Hydrophobicity_int_residues/1'>Hydrophobic regions</scene> on the alpha helices of the zinc binding domain participate in van der waals interactions that induce a conformational change in the protein when zinc binds. | <scene name='69/694239/Hydrophobicity_int_residues/1'>Hydrophobic regions</scene> on the alpha helices of the zinc binding domain participate in van der waals interactions that induce a conformational change in the protein when zinc binds. When Zinc binds, the <scene name='69/694239/Czbd_with_helices_labeled/2'>𝝰1 helix</scene> becomes straightened, burying nonpolar side-chain residues, influencing activity of DgcZ | ||
== Zinc Ligand(s) == | == Zinc Ligand(s) == | ||
The two <scene name='69/694239/Zinc_binding_domain/1'>Zinc binding domains</scene> of Diguanylate Cyclase binds a single zinc ion each, for a total of two zinc ions. | The two <scene name='69/694239/Zinc_binding_domain/1'>Zinc binding domains</scene> of Diguanylate Cyclase binds a single zinc ion each, for a total of two zinc ions. | ||