5u3s: Difference between revisions

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'''Unreleased structure'''


The entry 5u3s is ON HOLD  until Paper Publication
==Human PPARdelta ligand-binding domain in complexed with specific agonist 3==
 
<StructureSection load='5u3s' size='340' side='right' caption='[[5u3s]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
Authors: Wu, C.-C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Stockley-Noel, T.A., Bowman, M.E., Evans, R.M., Noel, J.P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5u3s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U3S FirstGlance]. <br>
Description: Human PPARdelta ligand-binding domain in complexed with specific agonist 3
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7V4:6-[2-({[4-(FURAN-3-YL)BENZENE-1-CARBONYL](PROPAN-2-YL)AMINO}METHYL)PHENOXY]HEXANOIC+ACID'>7V4</scene>, <scene name='pdbligand=B7G:HEPTYL-BETA-D-GLUCOPYRANOSIDE'>B7G</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5u3q|5u3q]], [[5u3r|5u3r]], [[5u3t|5u3t]], [[5u3u|5u3u]], [[5u3v|5u3v]], [[5u3w|5u3w]], [[5u3x|5u3x]], [[5u3y|5u3y]], [[5u3z|5u3z]], [[5u40|5u40]], [[5u41|5u41]], [[5u42|5u42]], [[5u44|5u44]], [[5u45|5u45]], [[5u46|5u46]]</td></tr>
[[Category: Wu, C.-C]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u3s OCA], [http://pdbe.org/5u3s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u3s RCSB], [http://www.ebi.ac.uk/pdbsum/5u3s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u3s ProSAT]</span></td></tr>
[[Category: La Clair, J.J]]
</table>
[[Category: Noel, J.P]]
== Function ==
[[Category: Richard, S.B]]
[[http://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN]] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref> 
[[Category: Atkins, A.R]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Atkins, A R]]
[[Category: Baiga, T J]]
[[Category: Bowman, M E]]
[[Category: Clair, J J.La]]
[[Category: Downes, M]]
[[Category: Downes, M]]
[[Category: Baiga, T.J]]
[[Category: Evans, R M]]
[[Category: Bowman, M.E]]
[[Category: Noel, J P]]
[[Category: Evans, R.M]]
[[Category: Richard, S B]]
[[Category: Stockley-Noel, T.A]]
[[Category: Stockley-Noel, T A]]
[[Category: Wu, C C]]
[[Category: Agonist]]
[[Category: Ligand-binding domain]]
[[Category: Ppardelta]]
[[Category: Protein binding-activator complex]]

Revision as of 19:45, 22 March 2017

Human PPARdelta ligand-binding domain in complexed with specific agonist 3Human PPARdelta ligand-binding domain in complexed with specific agonist 3

Structural highlights

5u3s is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PPARD_HUMAN] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.[1] [2]

References

  1. ↑ Schmidt A, Endo N, Rutledge SJ, Vogel R, Shinar D, Rodan GA. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol Endocrinol. 1992 Oct;6(10):1634-41. PMID:1333051 doi:http://dx.doi.org/10.1210/mend.6.10.1333051
  2. ↑ van der Veen JN, Kruit JK, Havinga R, Baller JF, Chimini G, Lestavel S, Staels B, Groot PH, Groen AK, Kuipers F. Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1. J Lipid Res. 2005 Mar;46(3):526-34. Epub 2004 Dec 16. PMID:15604518 doi:http://dx.doi.org/10.1194/jlr.M400400-JLR200

5u3s, resolution 2.00Å

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