5pyt: Difference between revisions

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-'''Unreleased structure'''
-The entry 5pyt is ON HOLD
+==PanDDA analysis group deposition -- Crystal Structure of SP100 after initial refinement with no ligand modelled (structure 89)==
+<StructureSection load='5pyt' size='340' side='right' caption='[[5pyt]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
-Authors: Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5pyt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5PYT FirstGlance]. <br>
-Description: PanDDA analysis group deposition --Crystal Structure of SP100 after initial refinement with no ligand modelled (structure 89)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5pyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pyt OCA], [http://pdbe.org/5pyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5pyt RCSB], [http://www.ebi.ac.uk/pdbsum/5pyt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5pyt ProSAT]</span></td></tr>
-[[Category: Pearce, N.M]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SP100_HUMAN SP100_HUMAN]] Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.<ref>PMID:11909962</ref> <ref>PMID:14647468</ref> <ref>PMID:15247905</ref> <ref>PMID:15592518</ref> <ref>PMID:15767676</ref> <ref>PMID:16177824</ref> <ref>PMID:17245429</ref> <ref>PMID:21274506</ref> <ref>PMID:21880768</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Bradley, A R]]
+[[Category: Brandao-Neto, J]]
+[[Category: Brennan, P E]]
 [[Category: Collins, P]]
 [[Category: Cox, O]]
-[[Category: Arrowsmith, C.H]]
+[[Category: Delft, F von]]
-[[Category: Brandao-Neto, J]]
+[[Category: Dias, A]]
+[[Category: Douangamath, A]]
+[[Category: Edwards, A]]
 [[Category: Fairhead, M]]
-[[Category: Von Delft, F]]
+[[Category: Krojer, T]]
+[[Category: MacLean, E]]
+[[Category: Ng, J]]
+[[Category: Pearce, N M]]
 [[Category: Renjie, Z]]
+[[Category: Sethi, R]]
+[[Category: Talon, R]]
 [[Category: Wright, N]]
-[[Category: Ng, J]]
+[[Category: Bromodomain]]
-[[Category: Bradley, A.R]]
+[[Category: Epigenetic]]
-[[Category: Talon, R]]
+[[Category: Pandda]]
-[[Category: Brennan, P.E]]
+[[Category: Sgc - diamond i04-1 fragment screening]]
-[[Category: Edwards, A]]
+[[Category: Transcription]]
-[[Category: Douangamath, A]]
+[[Category: Xchemexplorer]]
-[[Category: Maclean, E]]
-[[Category: Krojer, T]]
-[[Category: Dias, A]]
-[[Category: Sethi, R]]
-[[Category: Bountra, C]]