Sandbox Reserved 1066: Difference between revisions
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==Zinc Induced Conformation Change== | ==Zinc Induced Conformation Change== | ||
The ligand binding domains (CTD) and pore domains (TMD) are connected by the flexible loop that houses the charge interlock mechanism that helps hold the homodimer together. This flexible loop also acts as a hinge for the CTDs to come together and bind Zn at active site C. Zn binding to the CTD causes a conformation change in the TMD which ca | |||
==Allosteric Inhibition== | ==Allosteric Inhibition== | ||