5pod: Difference between revisions

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'''Unreleased structure'''


The entry 5pod is ON HOLD
==PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N07807b==
 
<StructureSection load='5pod' size='340' side='right' caption='[[5pod]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
Authors: Krojer, T.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5pod]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5POD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5POD FirstGlance]. <br>
Description: PanDDA analysis group deposition --Crystal Structure of BRD1 in complex with N07807b
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8T1:6-AMINO-1-METHYLQUINOLIN-2(1H)-ONE'>8T1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5pod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pod OCA], [http://pdbe.org/5pod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5pod RCSB], [http://www.ebi.ac.uk/pdbsum/5pod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5pod ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bradley, A R]]
[[Category: Brandao-Neto, J]]
[[Category: Brennan, P E]]
[[Category: Collins, P]]
[[Category: Cox, O]]
[[Category: Delft, F von]]
[[Category: Dias, A]]
[[Category: Douangamath, A]]
[[Category: Edwards, A]]
[[Category: Fairhead, M]]
[[Category: Krojer, T]]
[[Category: Krojer, T]]
[[Category: MacLean, E]]
[[Category: Ng, J]]
[[Category: Pearce, N M]]
[[Category: Renjie, Z]]
[[Category: Sethi, R]]
[[Category: Talon, R]]
[[Category: Wright, N]]
[[Category: Bromodomain]]
[[Category: Epigenetic]]
[[Category: Gene regulation]]
[[Category: Pandda]]
[[Category: Sgc - diamond i04-1 fragment screening]]
[[Category: Xchemexplorer]]

Revision as of 00:44, 16 March 2017

PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N07807bPanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N07807b

Structural highlights

5pod is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BRD1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.[1] [2]

References

  1. ↑ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 2006 Jan 6;21(1):51-64. PMID:16387653 doi:10.1016/j.molcel.2005.12.007
  2. ↑ Qin S, Jin L, Zhang J, Liu L, Ji P, Wu M, Wu J, Shi Y. Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF). J Biol Chem. 2011 Oct 21;286(42):36944-55. doi: 10.1074/jbc.M111.244400. Epub, 2011 Aug 31. PMID:21880731 doi:http://dx.doi.org/10.1074/jbc.M111.244400

5pod, resolution 1.56Å

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OCA
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