5irq: Difference between revisions

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-'''Unreleased structure'''
-The entry 5irq is ON HOLD  until Paper Publication
+==Human cytochrome P450 17A1 bound to inhibitors (R)- and (S)- orteronel==
+<StructureSection load='5irq' size='340' side='right' caption='[[5irq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-Authors: Scott, E.E., Petrunak, E.M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5irq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IRQ FirstGlance]. <br>
-Description: Human cytochrome P450 17A1 bound to inhibitors (R)-and (S)-orteronel
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6D7:(R)-ORTERONEL'>6D7</scene>, <scene name='pdbligand=7D6:(S)-ORTERONEL'>7D6</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5irv|5irv]]</td></tr>
-[[Category: Petrunak, E.M]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5irq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5irq OCA], [http://pdbe.org/5irq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5irq RCSB], [http://www.ebi.ac.uk/pdbsum/5irq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5irq ProSAT]</span></td></tr>
-[[Category: Scott, E.E]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN]] Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency;46,XY disorder of sex development due to isolated 17, 20 lyase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN]] Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.<ref>PMID:22266943</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Petrunak, E M]]
+[[Category: Scott, E E]]
+[[Category: Inhibitor complex]]
+[[Category: Lyase-inhibitor complex]]
+[[Category: Oxidoreductase]]