5wt9: Difference between revisions

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-'''Unreleased structure'''
-The entry 5wt9 is ON HOLD  until Paper Publication
+==Complex structure of PD-1 and nivolumab-Fab==
+<StructureSection load='5wt9' size='340' side='right' caption='[[5wt9]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5wt9]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WT9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WT9 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wt9 OCA], [http://pdbe.org/5wt9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wt9 RCSB], [http://www.ebi.ac.uk/pdbsum/5wt9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wt9 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN]] Systemic lupus erythematosus;Multiple sclerosis. Systemic lupus erythematosus 2 (SLEB2) [MIM:[http://omim.org/entry/605218 605218]]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.<ref>PMID:12402038</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.<ref>PMID:21276005</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Chai, Y]]
+[[Category: Gao, G F]]
+[[Category: Gao, S]]
+[[Category: Liu, W J]]
+[[Category: Qi, J]]
+[[Category: Shi, Y]]
+[[Category: Song, H]]
+[[Category: Tan, S]]
+[[Category: Tong, Z]]
+[[Category: Wang, Q]]
+[[Category: Wang, Z]]
+[[Category: Wong, G]]
+[[Category: Yan, J]]
+[[Category: Yang, F]]
+[[Category: Zhang, H]]
+[[Category: Zhu, X]]
+[[Category: Immune system]]
+[[Category: Nivolumab]]
+[[Category: Pd-1]]