5u76: Difference between revisions

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-'''Unreleased structure'''
-The entry 5u76 is ON HOLD
+==Chicken Slo2.2 in a closed conformation vitrified in the presence of 300 mM NaCl==
+<StructureSection load='5u76' size='340' side='right' caption='[[5u76]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5u76]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U76 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U76 FirstGlance]. <br>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5u70|5u70]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u76 OCA], [http://pdbe.org/5u76 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u76 RCSB], [http://www.ebi.ac.uk/pdbsum/5u76 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u76 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KCNT1_CHICK KCNT1_CHICK]] Generates outwardly rectifying currents that are suppressed by elevation of intracellular calcium.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The stable structural conformations that occur along the complete reaction coordinate for ion channel opening have never been observed. In this study, we describe the equilibrium ensemble of structures of Slo2.2, a neuronal Na+-activated K+ channel, as a function of the Na+ concentration. We find that Slo2.2 exists in multiple closed conformations whose relative occupancies are independent of Na+ concentration. An open conformation emerges from an ensemble of closed conformations in a highly Na+-dependent manner, without evidence of Na+-dependent intermediates. In other words, channel opening is a highly concerted, switch-like process. The midpoint of the structural titration matches that of the functional titration. A maximum open conformation probability approaching 1.0 and maximum functional open probability approaching 0.7 imply that, within the class of open channels, there is a subclass that is not permeable to ions.
-Authors: Hite, R.K., MacKinnon, R.
+Structural Titration of Slo2.2, a Na+-Dependent K+ Channel.,Hite RK, MacKinnon R Cell. 2017 Jan 26;168(3):390-399.e11. doi: 10.1016/j.cell.2016.12.030. Epub 2017 , Jan 19. PMID:28111072<ref>PMID:28111072</ref>
-Description: Chicken Slo2.2 in a closed conformation vitrified in the presence of 300 mM NaCl
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Mackinnon, R]]
+<div class="pdbe-citations 5u76" style="background-color:#fffaf0;"></div>
-[[Category: Hite, R.K]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Hite, R K]]
+[[Category: MacKinnon, R]]
+[[Category: Ion channel]]
+[[Category: Potassium channel]]
+[[Category: Transport protein]]