5f62: Difference between revisions

Revision as of 12:21, 10 March 2017

Crystal structure of the first bromodomain of human BRD4 in complex with MA4-022-2Crystal structure of the first bromodomain of human BRD4 in complex with MA4-022-2

Structural highlights

5f62 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	5f5z, 5f60, 5f61, 5f63
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.^[1] ^[2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

References

↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

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OCA

[1] French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779

[2] French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5f62 is ON HOLD  until Paper Publication
+==Crystal structure of the first bromodomain of human BRD4 in complex with MA4-022-2==
+<StructureSection load='5f62' size='340' side='right' caption='[[5f62]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5f62]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F62 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5W1:~{N}-[2-CHLORANYL-5-[[2-[[3-FLUORANYL-4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO]-5-METHYL-PYRIMIDIN-4-YL]AMINO]PHENYL]-2-METHYL-PROPANE-2-SULFONAMIDE'>5W1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f5z|5f5z]], [[5f60|5f60]], [[5f61|5f61]], [[5f63|5f63]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f62 OCA], [http://pdbe.org/5f62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f62 RCSB], [http://www.ebi.ac.uk/pdbsum/5f62 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f62 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Ember, S W]]
+[[Category: Schonbrunn, E]]
+[[Category: Zhu, J Y]]
+[[Category: Bromodomain]]
+[[Category: Cap]]
+[[Category: Cell cycle]]
+[[Category: Hunk1]]
+[[Category: Inhibitor]]
+[[Category: Mcap]]
+[[Category: Mitotic chromosome associated protein]]
+[[Category: Protein binding-inhibitor complex]]
+[[Category: Transcription-transcription inhibitor complex]]

5f62: Difference between revisions

Revision as of 12:21, 10 March 2017

Crystal structure of the first bromodomain of human BRD4 in complex with MA4-022-2Crystal structure of the first bromodomain of human BRD4 in complex with MA4-022-2

Structural highlights

Disease

Function

References

Contents

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5f62: Difference between revisions

Revision as of 12:21, 10 March 2017

Crystal structure of the first bromodomain of human BRD4 in complex with MA4-022-2Crystal structure of the first bromodomain of human BRD4 in complex with MA4-022-2

Structural highlights

Disease

Function

References

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