3woz: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of CLASP2 TOG domain (TOG3)== | ==Crystal structure of CLASP2 TOG domain (TOG3)== | ||
<StructureSection load='3woz' size='340' side='right' caption='[[3woz]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='3woz' size='340' side='right' caption='[[3woz]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
| Line 5: | Line 6: | ||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3woy|3woy]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3woy|3woy]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3woz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3woz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3woz RCSB], [http://www.ebi.ac.uk/pdbsum/3woz PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3woz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3woz OCA], [http://pdbe.org/3woz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3woz RCSB], [http://www.ebi.ac.uk/pdbsum/3woz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3woz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
Revision as of 20:26, 9 March 2017
Crystal structure of CLASP2 TOG domain (TOG3)Crystal structure of CLASP2 TOG domain (TOG3)
Structural highlights
Function[CLAP2_MOUSE] Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). |
| ||||||||||||||||||