Mutations in BRCA1/BARD1 RING-domain heterodimer: Difference between revisions

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Alexander Berchansky, Jaime Prilusky, Joel L. Sussman, Michal Harel

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   </jmolLink>
 </jmol> between the two states. This mutation causes missing of S-Zn bond.
-*'''Mutation C44Y:''' <scene name='75/751104/C44y/3'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/C44y/1'>Mutated and wildtype residues together</scene>. <scene name='75/751104/C44y/2'>Click here to see animation of this scene</scene> This mutation causes missing of S-Zn bond.
+*<scene name='75/751104/C44y/3'>Mutation C44Y:</scene>
+<jmol>
+ <jmolLink>
+  <script>
+    animation on; animation mode loop; frame 1 1 play; animation off; frame 1; select [CYS]44;color selectionHalos green;selectionHalos on;
+  </script>
+ <text>Wild type </text>
+ </jmolLink>
+</jmol>
+conformation and
+<jmol>
+ <jmolLink>
+  <script>
+    animation on; animation mode loop; frame 2 2 play; animation off; frame 2; select [TYR]44;color selectionHalos red;selectionHalos on;
+  </script>
+  <text>mutation.
+  </text>
+ </jmolLink>
+</jmol>
+Click here to see the
+<jmol>
+ <jmolLink>
+  <script>
+    animation off; frame all; select [TYR]44;color selectionHalos red;selectionHalos on;
+  </script>
+  <text>mutated and wild type
+  </text>
+ </jmolLink>
+</jmol> residues together, and an
+<jmol>
+ <jmolLink>
+  <script>
+   animation on; animation mode loop; frame play; select [TYR]44;color selectionHalos red;selectionHalos on;
+  </script>
+  <text>animation
+  </text>
+ </jmolLink>
+</jmol> between the two states. This mutation causes missing of S-Zn bond.
 *'''Mutation C61G:''' <scene name='75/751104/C61g/3'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/C61g/1'>Mutated and wildtype residues together</scene>. <scene name='75/751104/C61g/2'>Click here to see animation of this scene</scene> This mutation causes missing of S-Zn bond.