Mutations in BRCA1/BARD1 RING-domain heterodimer: Difference between revisions
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</jmolLink> | </jmolLink> | ||
</jmol> between the two states. | </jmol> between the two states. | ||
* | *<scene name='75/751104/C39r/1'>Mutation C39R:</scene> | ||
<jmol> | |||
<jmolLink> | |||
<script> | |||
animation on; animation mode loop; frame 1 1 play; animation off; frame 1; select [CYS]39;color selectionHalos green;selectionHalos on; | |||
</script> | |||
<text>Wild type </text> | |||
</jmolLink> | |||
</jmol> | |||
conformation and | |||
<jmol> | |||
<jmolLink> | |||
<script> | |||
animation on; animation mode loop; frame 2 2 play; animation off; frame 2; select [ARG]39;color selectionHalos red;selectionHalos on; | |||
</script> | |||
<text>mutation. | |||
</text> | |||
</jmolLink> | |||
</jmol> | |||
Click here to see the | |||
<jmol> | |||
<jmolLink> | |||
<script> | |||
animation off; frame all; select [ARG]39;color selectionHalos red;selectionHalos on; | |||
</script> | |||
<text>mutated and wild type | |||
</text> | |||
</jmolLink> | |||
</jmol> residues together, and an | |||
<jmol> | |||
<jmolLink> | |||
<script> | |||
animation on; animation mode loop; frame play; select [ARG]39;color selectionHalos red;selectionHalos on; | |||
</script> | |||
<text>animation | |||
</text> | |||
</jmolLink> | |||
</jmol> between the two states. This mutation causes missing of S-Zn bond. | |||
*'''Mutation H41R:''' <scene name='75/751104/H41r/5'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/H41r/3'>Mutated and wildtype residues together</scene>. <scene name='75/751104/H41r/4'>Click here to see animation of this scene</scene>. This mutation causes missing of N-Zn bond. | *'''Mutation H41R:''' <scene name='75/751104/H41r/5'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/H41r/3'>Mutated and wildtype residues together</scene>. <scene name='75/751104/H41r/4'>Click here to see animation of this scene</scene>. This mutation causes missing of N-Zn bond. | ||
*'''Mutation C44S:''' <scene name='75/751104/C44s/3'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/C44s/1'>Mutated and wildtype residues together</scene>. <scene name='75/751104/C44s/2'>Click here to see animation of this scene</scene>. This mutation causes missing of S-Zn bond. | *'''Mutation C44S:''' <scene name='75/751104/C44s/3'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/C44s/1'>Mutated and wildtype residues together</scene>. <scene name='75/751104/C44s/2'>Click here to see animation of this scene</scene>. This mutation causes missing of S-Zn bond. | ||