Contactin: Difference between revisions

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New page: <StructureSection load='5i99' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Contactin''' (CNTN) is a neuronal cell surface glycoprotein which a...
 
Michal Harel (talk | contribs)
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<StructureSection load='5i99' size='340' side='right' caption='Mouse contactin-3 domains Ig1-Ig4 complex with glycerol (PDB code [[5i99]])' scene=''>
<StructureSection load='5i99' size='340' side='right' caption='Caption for this structure' scene=''>


== Function ==
== Function ==
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== Disease ==
== Disease ==
contactin-4 is an autism susceptibility locus<ref>PMID:21308999</ref>.
contactin-4 is an autism susceptibility locus<ref>PMID:21308999</ref>.
== Relevance ==
== Structural highlights ==


</StructureSection>
</StructureSection>

Revision as of 13:33, 29 January 2017


Function

Contactin (CNTN) is a neuronal cell surface glycoprotein which associates with sodium channel and enhances the density of these channels on the plasma membrane in mammalian expression systems[1].

Disease

contactin-4 is an autism susceptibility locus[2].


Mouse contactin-3 domains Ig1-Ig4 complex with glycerol (PDB code 5i99)

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3D structures of contactin3D structures of contactin

Updated on 29-January-2017

ReferencesReferences

  1. Rush AM, Craner MJ, Kageyama T, Dib-Hajj SD, Waxman SG, Ranscht B. Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons. Eur J Neurosci. 2005 Jul;22(1):39-49. PMID:16029194 doi:http://dx.doi.org/10.1111/j.1460-9568.2005.04186.x
  2. Cottrell CE, Bir N, Varga E, Alvarez CE, Bouyain S, Zernzach R, Thrush DL, Evans J, Trimarchi M, Butter EM, Cunningham D, Gastier-Foster JM, McBride KL, Herman GE. Contactin 4 as an autism susceptibility locus. Autism Res. 2011 Jun;4(3):189-99. doi: 10.1002/aur.184. Epub 2011 Feb 9. PMID:21308999 doi:http://dx.doi.org/10.1002/aur.184

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Michal Harel