IGF1: Difference between revisions
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=== Stimulating interaction : IGF-1 - IGF-1R === | === Stimulating interaction : IGF-1 - IGF-1R === | ||
'''Insulin-like Growth Factor 1 Receptor''' ('''IGF-1R''') is a transmembrane protein receptor. It is composed of two α subunits and two tyrosine β subunits. Both α subunits are '' | '''Insulin-like Growth Factor 1 Receptor''' ('''IGF-1R''') is a transmembrane protein receptor. It is composed of two α subunits and two tyrosine β subunits. Both α subunits are <scene name='75/751772/Igf1r/2'>cystein-rich region</scene> and therefore linked with a '''disulfide bond'''. Ligand-binding on α subunit induces activation of β subunit by autophosphorylation. It further leads to activation of the Akt and mTor pathways inside the cell. <ref>http://www.exobiologie.info/diabete/10%20recepteur.pdf, 27/01/2016</ref> | ||
[[Image:Interactions_IGF_refait.PNG | 300 px |left]] | [[Image:Interactions_IGF_refait.PNG | 300 px |left]] | ||
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Therefore, the various concentration of the insulin proteins regulates the cell activity in different context, for instance in excess of glucose or lack of Growth Hormone. | Therefore, the various concentration of the insulin proteins regulates the cell activity in different context, for instance in excess of glucose or lack of Growth Hormone. | ||
Recent research demonstrated that the homology between IGF-1R and the '''insulin receptor''' (IR) subunits allow them to bind and form a functionnal hybrid IR/IGF-1R receptor. | Recent research demonstrated that the homology between IGF-1R and the '''insulin receptor''' (IR) subunits allow them to bind and form a functionnal hybrid IR/IGF-1R receptor. The exact residues interacting with one another are not known accuraretly but the docking mechanism is the same as for IGFBP. | ||