IGF1: Difference between revisions
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=== Stimulating interaction : IGF-1 - IGF-1R === | === Stimulating interaction : IGF-1 - IGF-1R === | ||
'''Insulin-like Growth Factor 1 Receptor''' ('''IGF-1R''') is a transmembrane protein receptor. It is composed of two α subunits and two tyrosine β subunits. Both α subunits are '''cysteine-rich region''' and therefore linked with a '''disulfide bond'''. Ligand-binding on α subunit induces activation of β subunit by autophosphorylation. It further leads to activation of the Akt and mTor pathways inside the cell. | '''Insulin-like Growth Factor 1 Receptor''' ('''IGF-1R''') is a transmembrane protein receptor. It is composed of two α subunits and two tyrosine β subunits. Both α subunits are '''cysteine-rich region''' and therefore linked with a '''disulfide bond'''. Ligand-binding on α subunit induces activation of β subunit by autophosphorylation. It further leads to activation of the Akt and mTor pathways inside the cell. <ref>http://www.exobiologie.info/diabete/10%20recepteur.pdf, 27/01/2016</ref> | ||
[[Image:Interactions_IGF_refait.PNG | 300 px |left]] | [[Image:Interactions_IGF_refait.PNG | 300 px |left]] | ||