IGF1: Difference between revisions
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=== Stimulating interaction : IGF1 - IGF1R === | === Stimulating interaction : IGF1 - IGF1R === | ||
'''Insulin-like Growth Factor 1 Receptor''' ('''IGF1R''') is a transmembrane protein receptor. It is composed of two alpha subunits and two tyrosine beta subunits. Both alpha subunits are cysteine-rich region and therefore linked with a disulfide bond. Ligand-binding on alpha subunit induces activation of beta subunit by autophosphorylation. It further leads to activation of the Akt and mTor pathways inside the cell. | '''Insulin-like Growth Factor 1 Receptor''' ('''IGF1R''') is a transmembrane protein receptor. It is composed of two alpha subunits and two tyrosine beta subunits. Both alpha subunits are cysteine-rich region and therefore linked with a disulfide bond. Ligand-binding on alpha subunit induces activation of beta subunit by autophosphorylation. It further leads to activation of the Akt and mTor pathways inside the cell. | ||