User:Manon Raiffort/Sandbox: Difference between revisions

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*''' Coagulation''' = Secondary Haemostasis : The goal of this step is to create a thrombus. Numerous coagulated factors are involved during this process. The plasma procoagulant co-enzyme Factor VIII plays a central role in the coagulation : catalyses activation of factor X and stabilizes the thrombus which stop the bleeding. vWF acts as a carrier for this factor. The factor VIII is bound to two domains : D'/D3. Without vWF the factor VIII will be cleaved by serin proteases.

* Interaction with '''[[Collagen]]''' : On the one hand the A1 and A3 domains of vWF link to the collagen of the subepithelium and on the other hand it binds to the platelets thanks to Gp Ib receptor<ref>[[Huizinga et el. (1997)Crystal structure of the A3 domain of human von Willebrand factor: implications for collagen binding]], http://www.cell.com/structure/fulltext/S0969-2126(97)00266-9.</ref>.

* Interaction with '''[[Collagen]]''' : On the one hand the A1 and A3 domains of vWF link to the collagen of the subepithelium and on the other hand it binds to the platelets thanks to Gp Ib receptor <ref>[[Huizinga et el. (1997)Crystal structure of the A3 domain of human von Willebrand factor: implications for collagen binding]], http://www.cell.com/structure/fulltext/S0969-2126(97)00266-9.</ref>.

* Interaction with receptor of '''platelet integrins αIIb/β3 ''' by the C1 domain which contains the RGD pattern : Arg-Gly-Asp

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== References ==

*Kazuo Fujikawa et al. (2001). Purification of human von Willebrand factor–cleaving protease and its identification as a new member of the metalloproteinase family. Blood http://www.bloodjournal.org/content/98/6/1662.long?sso-checked=true <references/>

*Eric G Huizinga1 et al. (1997) Crystal structure of the A3 domain of human von Willebrand factor: implications for collagen binding. Cell Press <references/>

*Zaverio M. Ruggeri (2001). Structure of von Willebrand factor and its function in platelet adhesion and thrombus formation. Elsevier <references/>

@@ Line 31: / Line 31: @@
 *''' Coagulation''' = Secondary Haemostasis : The goal of this step is to create a thrombus. Numerous coagulated factors are involved during this process. The plasma procoagulant co-enzyme Factor VIII plays a central role in the coagulation : catalyses activation of factor X and stabilizes the thrombus which stop the bleeding. vWF acts as a carrier for this factor. The factor VIII is bound to two domains : D'/D3. Without vWF the factor VIII will be cleaved by serin proteases.
-* Interaction with '''[[Collagen]]''' : On the one hand the A1 and A3 domains of vWF link to the collagen of the subepithelium and on the other hand it binds to the platelets thanks to Gp Ib receptor<ref>[[Huizinga et el. (1997)Crystal structure of the A3 domain of human von Willebrand factor: implications for collagen binding]], http://www.cell.com/structure/fulltext/S0969-2126(97)00266-9.</ref>.
+* Interaction with '''[[Collagen]]''' : On the one hand the A1 and A3 domains of vWF link to the collagen of the subepithelium and on the other hand it binds to the platelets thanks to Gp Ib receptor <ref>[[Huizinga et el. (1997)Crystal structure of the A3 domain of human von Willebrand factor: implications for collagen binding]], http://www.cell.com/structure/fulltext/S0969-2126(97)00266-9.</ref>.
 * Interaction with receptor of '''platelet integrins αIIb/β3 ''' by the C1 domain which contains the RGD pattern : Arg-Gly-Asp
@@ Line 73: / Line 73: @@
 == References ==
 *Kazuo Fujikawa et al. (2001). Purification of human von Willebrand factor–cleaving protease and its identification as a new member of the metalloproteinase family. Blood http://www.bloodjournal.org/content/98/6/1662.long?sso-checked=true <references/>
-*Eric G Huizinga1 et al. (1997) Crystal structure of the A3 domain of human von Willebrand factor: implications for collagen binding. Cell Press <references/>
 *Zaverio M. Ruggeri (2001). Structure of von Willebrand factor and its function in platelet adhesion and thrombus formation. Elsevier <references/>