User:Manon Raiffort/Sandbox: Difference between revisions

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== Function ==

Von Willebrand factor has several functions in ~~diferent~~ phenomenon :

Von Willebrand factor has several functions in different phenomenon :

* '''Primary haemostasis''' : Afer a damaged of blood vessels, platelets will adhere to subendothelium which is a thrombogenic surface thanks to vWF. The platelet plug is formed thaks to the platelets aggregation. Domain A1 of vWF links to the receptor Gp-1b-IX-V, which is found on platelet.

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=== A3 domain ===

A3 domain is a domain of 20kDa between the residues 920 to 1111 of the von willebrand factor.

It has <scene name='75/750301/Secondary_structure/1'> a dinucleotide-binding fold </scene>. This is a structure in which a central β sheet is encompassed by <scene name='75/750301/Alpha_helix/1'>7 α-helix</scene> (named α1 to α7) connected by loops. The β sheet is composed by 6 strands (named respectively β1 to β6) and are all parallel except the β3 which is on the sheet’s edge.

It has <scene name='75/750301/Secondary_structure/1'> a dinucleotide-binding fold </scene>. This is a structure in which a central β sheet is encompassed by <scene name='75/750301/Alpha_helix/1'>7 α-helix</scene> (named α1 to α7) connected by loops. The β sheet (yellow) is composed by 6 strands (named respectively β1 to β6) and are all parallel except the β3 which is on the sheet’s edge.

In this domain, two cysteine residues (923 and 1109) put the N-terminal and C-terminal region together by a disulfide bond.

The A3 domain is composed of negative charged and this allows the interaction with the collagen which has positive charged residues on it.

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

== References ==

@@ Line 25: / Line 25: @@
 == Function ==
-Von Willebrand factor has several functions in diferent phenomenon :
+Von Willebrand factor has several functions in different phenomenon :
 * '''Primary haemostasis''' : Afer a damaged of blood vessels, platelets will adhere to subendothelium which is a thrombogenic surface thanks to vWF. The platelet plug is formed thaks to the platelets aggregation. Domain A1 of vWF links to the receptor Gp-1b-IX-V, which is found on platelet.
@@ Line 66: / Line 66: @@
 === A3 domain ===
 A3 domain is a domain of 20kDa between the residues 920 to 1111 of the von willebrand factor.
-It has <scene name='75/750301/Secondary_structure/1'> a dinucleotide-binding fold </scene>. This is a structure in which a central β sheet is encompassed by <scene name='75/750301/Alpha_helix/1'>7 α-helix</scene>  (named α1 to α7)  connected by loops. The β sheet is composed by 6 strands (named respectively β1 to β6) and are all parallel except the β3 which is on the sheet’s edge.
+It has <scene name='75/750301/Secondary_structure/1'> a dinucleotide-binding fold </scene>. This is a structure in which a central β sheet is encompassed by <scene name='75/750301/Alpha_helix/1'>7 α-helix</scene>  (named α1 to α7)  connected by loops. The β sheet (yellow) is composed by 6 strands (named respectively β1 to β6) and are all parallel except the β3 which is on the sheet’s edge.
 In this domain, two cysteine residues (923 and 1109) put the N-terminal and C-terminal region together by a disulfide bond.
 The A3 domain is composed of negative charged and this allows the interaction with the collagen which has positive charged residues on it.
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
 == References ==