5i5c: Difference between revisions

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'''Unreleased structure'''


The entry 5i5c is ON HOLD  until Paper Publication
==X-ray crystal structure of allo-Thr31-ShK==
 
<StructureSection load='5i5c' size='340' side='right' caption='[[5i5c]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
Authors: Dang, B., Kubota, T., Manda, K.l., Shen, R., Bezanilla, F., Roux, B., Kent, S.B.H.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5i5c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I5C FirstGlance]. <br>
Description: X-ray crystal structure of allo-Thr31-ShK
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALO:ALLO-THREONINE'>ALO</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5i5a|5i5a]], [[5i5b|5i5b]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i5c OCA], [http://pdbe.org/5i5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i5c RCSB], [http://www.ebi.ac.uk/pdbsum/5i5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i5c ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/K1A_STIHL K1A_STIHL]] Inhibits voltage-dependent potassium channels. Inhibits Kv1.3/KCNA3 potently and also blocks Kv1.1/KCNA1, Kv1.4/KCNA4, and Kv1.6/KCNA6 at subnanomolar concentrations.<ref>PMID:7660365</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bezanilla, F]]
[[Category: Bezanilla, F]]
[[Category: Dang, B]]
[[Category: Kent, S B.H]]
[[Category: Kubota, T]]
[[Category: Kubota, T]]
[[Category: Manda, K.L]]
[[Category: Manda, K l]]
[[Category: Roux, B]]
[[Category: Roux, B]]
[[Category: Dang, B]]
[[Category: Shen, R]]
[[Category: Shen, R]]
[[Category: Kent, S.B.H]]
[[Category: Allo-thr31-shk]]
[[Category: Toxin]]

Revision as of 02:43, 26 January 2017

X-ray crystal structure of allo-Thr31-ShKX-ray crystal structure of allo-Thr31-ShK

Structural highlights

5i5c is a 3 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
NonStd Res:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[K1A_STIHL] Inhibits voltage-dependent potassium channels. Inhibits Kv1.3/KCNA3 potently and also blocks Kv1.1/KCNA1, Kv1.4/KCNA4, and Kv1.6/KCNA6 at subnanomolar concentrations.[1]

References

  1. ↑ Castaneda O, Sotolongo V, Amor AM, Stocklin R, Anderson AJ, Harvey AL, Engstrom A, Wernstedt C, Karlsson E. Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus. Toxicon. 1995 May;33(5):603-13. PMID:7660365

5i5c, resolution 1.30Å

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